BACKGROUND To compare the accuracy, advantages and disadvantages of automatic registration methods at different anatomical-sites for thoracic image-guided radiation therapy (IGRT). METHODS The Varian-IX IGRT system was used to perform a manual registration of the images collected on the first fraction of 60 patients with lung cancer (42 cases central location and 18 cases of peripheral). The registered images were used as reference images. Offline registration was performed for computed tomography-CBCT images using four methods: whole image registration, ipsilateral registration, soft tissue tumor registration, and vertebral body registration. Time taken to complete and deviation value were analyzed between the different methods. RESULTS There were significant differences in absolute deviation value of all the three directions (P < 0.001) and the time consumption (P < 0.001) between 4 methods. The Z direction had significant differences in deviation value of 4 methods (0.023 ± 0.128 mm, - 0.030 ± 0.175 mm, - 0.010 ± 0.238 mm, - 0.075 ± 0.137 mm, P = 0.011). The difference was significant in the X direction of the ipsilateral registration method between central and peripheral lung cancer (0.033 ± 0.053 mm vs. 0.067 ± 0.067 mm, P = 0.045). CONCLUSIONS The whole lung or affected side registration methods could be recommended to be used in the automatic registration function of the Varian-IX's On-Board Imaging (OBI) system.

中文翻译：

---

肺肿瘤影像引导放射治疗的不同注册方法和界标的比较。

背景技术为了比较自动配准方法在胸腔图像引导放射治疗（IGRT）在不同解剖部位的准确性，优缺点。方法使用Varian-IX IGRT系统对60例肺癌患者的第一部分（中心部位42例，周围部位18例）收集的图像进行手动配准。将注册图像用作参考图像。使用四种方法对计算机断层扫描CBCT图像进行脱机配准：全图像配准，同侧配准，软组织肿瘤配准和椎体配准。完成时间和偏差值在不同方法之间进行了分析。结果三个方向的绝对偏差值均存在显着差异（P <0。001）和4种方法之间的时间消耗（P <0.001）。Z方向在4种方法的偏差值上有显着差异（0.023±0.128 mm，-0.030±0.175 mm，-0.010±0.238 mm，-0.075±0.137 mm，P = 0.011）。在同侧配准方法的X方向上，中心型和周围型肺癌之间的差异是显着的（0.033±0.053 mm对0.067±0.067 mm，P = 0.045）。结论可以建议在Varian-IX车载成像（OBI）系统的自动配准功能中使用整个肺部或受影响的侧面配准方法。在同侧配准方法的X方向上，中心型和周围型肺癌之间的差异是显着的（0.033±0.053 mm对0.067±0.067 mm，P = 0.045）。结论可以建议在Varian-IX车载成像（OBI）系统的自动配准功能中使用整个肺部或受影响的侧面配准方法。在同侧配准方法的X方向上，中心型和周围型肺癌之间的差异是显着的（0.033±0.053 mm对0.067±0.067 mm，P = 0.045）。结论可以建议在Varian-IX车载成像（OBI）系统的自动配准功能中使用整个肺部或受影响的侧面配准方法。