BACKGROUND The following study investigates the involvement of optic neuropathy in IgG4-related ophthalmic diseases (IgG4-ROD) based on the magnetic resonance imaging (MRI) data, and different imaging features of IgG4-ROD related optic neuropathy related to other orbital diseases. METHODS This retrospective study included 225 patients with IgG4-RD admitted at two ophthalmology centers between January 2014 and December 2017. Twenty-six patients had both pre-therapeutic orbital MRI and optic never injury. The causes of optic neuropathy were analyzed, and the special sign in MRI to diagnose IgG4-ROD was also evaluated. RESULTS Twelve cases had inflammation of the optic nerve sheath, while 14 cases had compression due to extraocular muscles and pseudo tumor masses. Two cases had hypertrophic cranial pachymeningitis, while one case had hypophysis involving optic chiasma. CONCLUSION The most common causes of optic nerve injury in IgG-4 ROD are inflammation of optic nerve sheath, compression of extraocular muscles, pseudo tumor mass and hypertrophic cranial pachymeningitis, and hypophysis involving optic chiasma.

中文翻译：

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磁共振成像指示物，与IgG4相关的眼科疾病的视神经病变的原因有关。

背景技术以下研究基于磁共振成像（MRI）数据以及与其他眼眶疾病相关的IgG4-ROD相关性视神经病变的不同成像特征，研究了视神经病变与IgG4相关眼科疾病（IgG4-ROD）的关系。方法这项回顾性研究包括2014年1月至2017年12月在两个眼科中心收治的225例IgG4-RD患者。26例患者同时接受了治疗前眼眶MRI和视力永不损伤。分析了视神经病变的原因，并评估了MRI诊断IgG4-ROD的特殊体征。结果12例有视神经鞘炎，14例因眼外肌和假瘤肿块受压。2例患有肥厚性颅脑膜脑炎，1例有视神经下垂的垂体。结论IgG-4 ROD中最常见的视神经损伤原因是视神经鞘发炎，眼外肌受压，假性肿瘤块和肥厚性颅脑膜脑炎以及涉及视神经chi裂的垂体。