BACKGROUND This study aimed to investigate the image quality and adverse events (AEs) of ethiodized poppyseed oil (EPO) compared with ioversol as contrast agents in hysterosalpingography (HSG). METHODS Two hundred twenty-eight patients underwent HSG were consecutively recruited in this prospective cohort study, and were accordingly divided into EPO group (N = 165) and ioversol group (N = 63). The quality of image was assessed according to the European Guidelines on quality criteria for diagnostic radiographic images. AEs during, within 2 h and at 1-month post-HSG were recorded. RESULTS EPO displayed elevated image quality compared with ioversol including the total image quality score (P < 0.001), the cervical canal display score (P < 0.001), shape and outline of uterus score (P < 0.01), cervical mucosa or folds score (P < 0.001), oviduct isthmus score (P < 0.001), ampulla and fimbriae of oviduct score (P < 0.001) and celiac diffuse image score (P < 0.001). Multivariate linear regression displayed that EPO (P < 0.001) was an independent predictive factor for increased total image quality score. AEs were similar between EPO group and ioversol group during and within 2 h post-HSG (all P > 0.05). However, at 1-month post-HSG, the number of patients had unchanged and faded menstrual blood color decreased but the proportion of patients with deepened menstrual color increased in EPO group compared with ioversol group (P = 0.007). In addition, the number of patients had iodine residue in uterine cavity was elevated in EPO group compared with ioversol group (P < 0.001). CONCLUSION EPO is more efficient in image quality and equally tolerant compared to ioversol as contrast agents in HSG.

中文翻译：

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Ethiodized罂粟籽油与ioversol在子宫输卵管造影术中的图像质量和不良事件：前瞻性队列研究。

背景技术这项研究旨在研究子宫输卵管造影术（HSG）中与碘化酚作为对比剂相比，硫磺化罂粟籽油（EPO）的图像质量和不良事件（AE）。方法这项前瞻性队列研究连续招募了28位接受过HSG治疗的患者，将其分为EPO组（N = 165）和艾佛索尔组（N = 63）。根据欧洲放射线诊断影像质量标准指南对影像质量进行了评估。记录HSG后，2小时内和1个月内的不良事件。结果EPO与ioversol相比具有更高的图像质量，包括总图像质量得分（P <0.001），子宫颈管显示得分（P <0.001），子宫的形状和轮廓得分（P <0.01），宫颈粘膜或褶皱得分（ P <0.001），输卵管峡部评分（P <0.001），输卵管壶腹和菌毛评分（P <0.001）和腹腔弥散性图像评分（P <0.001）。多元线性回归显示，EPO（P <0.001）是提高总图像质量得分的独立预测因素。在HSG发生期间和之后2小时内，EPO组和ioversol组之间的AE相似（所有P> 0.05）。但是，HSG后1个月，EPO组患者的月经量不变并减少，月经血色减少，但与艾泊索组相比，月经颜色加深的患者比例有所增加（P = 0.007）。另外，EPO组的子宫腔内有碘残留的患者的数量高于碘泊酚组（P <0.001）。