Magnetic resonance arthrography (MRA) requires intra-articular injection of gadolinium-based diluted paramagnetic contrast material. To our knowledge, gadobenate dimeglumine (Gd-BOPTA) has never been used for intra-articular applications. Our aim was to test in vitro different concentrations of Gd-BOPTA to be potentially used to perform MRA. Gd-BOPTA was diluted in saline (NaCl 0.9%) to achieve different concentrations (4 mmol/l; 2 mmol/l; 1 mmol/l; 0.67 mmol/l; 0.5 mmol/l). Six sets of five sterile pipes were prepared with 5 ml of each solution, five sets added with 0.5 ml of fresh synovial fluid. Two separate pipes were prepared with 5 ml of gadopentetate dimeglumine (Gd-DTPA) at 2 mmol/l, one pipe added with 0.5 ml of synovial fluid. Pipes were imaged using a T1-weighted sequence at 1.5 T. For each pipe, signal intensity (SI) in arbitrary units (au) was measured. SI reproducibility range was 86–99%. Mean Gd-BOPTA SI in pipes containing synovial fluid increased from 1236 ± 8au (0.5 mmol/l) up to 1610 ± 44au (1 mmol/l) and down to 1405 ± 33au (4 mmol/l). Mean Gd-BOPTA SI in pipes without synovial fluid increased from 1184 ± 29au (0.5 mmol/l) up to 1530 ± 38au (1 mmol/l), and down to 1347 ± 39au (4 mmol/l). SI of pipes without synovial fluid was lower than that of pipes with synovial fluid for both Gd-BOPTA and Gd-DTPA (P ≤ 0.002). Regarding pipes with synovial fluid, mean Gd-DTPA SI at 2 mmol/l was 1246 ± 27au. Compared with Gd-BOPTA, SI was not different at 0.5 mmol/l (− 0.2%, P = 0.587) while it was higher (P < 0.001) at all other concentrations (range + 13.3%[4 mmol/l] − + 28.3%[1 mmol/l]). Regarding pipes without synovial fluid, mean Gd-DTPA SI at 2 mmol/l was 1275 ± 56au. Compared with Gd-BOPTA, SI was lower at 0.5 mmol/l (− 6.8%,P < 0.001), while it was higher (P < 0.001) at all other concentrations (range + 6.1%[4 mmol/l] − + 19.6% [1 mmol/l]). In vitro, Gd-BOPTA at 1 mmol/ had a + 28% SI increase in comparison to Gd-DTPA 2 mmol/l. SI similar to Gd-DTPA can be obtained using one fourth concentration of Gd-BOPTA.

中文翻译：

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稀释的高松弛度based基关节内造影剂在磁共振关节造影中的潜在用途：一项体外研究

磁共振关节造影（MRA）需要关节腔内注射g基稀释的顺磁对比剂。据我们所知，g酸二聚丁二胺（Gd-BOPTA）从未用于关节内应用。我们的目标是在体外测试可能用于执行MRA的不同浓度的Gd-BOPTA。将Gd-BOPTA稀释在盐水（NaCl 0.9％）中以达到不同的浓度（4 mmol / l； 2 mmol / l； 1 mmol / l； 0.67 mmol / l； 0.5 mmol / l）。制备六组五个无菌管，每种溶液5 ml，五组添加0.5 ml新鲜滑液。用5 ml浓度为2 mmol / l的ado戊二酸酯二葡甲胺（Gd-DTPA）制备两根单独的管，一根管中加入0.5 ml滑液。使用T1加权序列在1.5 T下对管道进行成像。对于每个管道，测量任意单位（au）的信号强度（SI）。SI的重现性范围为86–99％。含有滑液的管道中的平均Gd-BOPTA SI从1236±8au（0.5 mmol / l）上升到1610±44au（1 mmol / l），然后下降到1405±33au（4 mmol / l）。没有滑液的管道中的平均Gd-BOPTA SI从1184±29au（0.5 mmol / l）上升到1530±38au（1 mmol / l），再下降到1347±39au（4 mmol / l）。对于Gd-BOPTA和Gd-DTPA，没有滑液的管道的SI均比具有滑液的管道的SI低（P≤0.002）。对于带有滑液的管道，平均Gd-DTPA SI在2 mmol / l下为1246±27au。与Gd-BOPTA相比，SI在0.5 mmol / l时无差异（-0.2％，P = 0.587），而在所有其他浓度（范围+ 13.3％[4 mmol / l]-+时）都更高（P <0.001）。 28.3％[1 mmol / l]）。对于没有滑液的管道，2 mmol / l的Gd-DTPA SI平均值为1275±56au。与Gd-BOPTA相比，SI在0.5 mmol / l时较低（-6.8％，P <0.001），而在所有其他浓度（范围+ 6.1％[4 mmol / l]-+时）都较高（P <0.001）。 19.6％[1 mmol / l]。在体外，与2 mmol / l的Gd-DTPA相比，1 mmol /的Gd-BOPTA的SI增加了28％。使用Gd-BOPTA的四分之一浓度可以获得类似于Gd-DTPA的SI。