This meta-analysis was performed to evaluate the relationship between hypoxia-inducible factor-1α (HIF1α) 1790G/A gene polymorphism and the susceptibility to renal cell carcinoma (RCC) and prostate cancer (PCa). Association investigations were identified and included from the Embase, Cochrane Library and PubMed databases on March 1, 2018, and eligible investigations were analyzed by meta-analysis. Odds ratios (OR) were used to express the dichotomous data, and the 95% confidence intervals (CI) were also calculated. In this meta-analysis, we found that the AA genotype of HIF1α 1790G/A was positively associated with the risk of RCC in overall populations, Caucasians, but not for Asians. G allele and GG genotype were not associated with the susceptibility of RCC in overall populations, Caucasians, and Asians. The G allele was negatively associated with PCa susceptibility in overall populations, Asians, but not for Caucasians. GG genotype was negatively associated with PCa susceptibility in Asians, but not for overall populations and Caucasians. HIF1α 1790G/A AA genotype was not associated with PCa susceptibility in overall populations of Caucasians or Asians. AA genotype of HIF1α 1790G/A was positively associated with RCC risk in overall populations and Caucasians. Furthermore, the G allele was negatively associated with prostate cancer susceptibility in overall populations, Asians, and GG genotype was negatively associated with PCa susceptibility in Asians.

中文翻译：

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缺氧诱导因子-1α（HIF1α）1790G / A基因多态性与肾细胞癌和前列腺癌易感性的关联：荟萃分析

进行这项荟萃分析，以评估缺氧诱导因子-1α（HIF1α）1790G / A基因多态性与对肾细胞癌（RCC）和前列腺癌（PCa）的敏感性之间的关系。协会调查于2018年3月1日被确定并包括在Embase，Cochrane图书馆和PubMed数据库中，并通过荟萃分析对符合条件的调查进行了分析。用几率（OR）表示二分法的数据，并且还计算了95％的置信区间（CI）。在这项荟萃分析中，我们发现HIF1α1790G / A的AA基因型与总体人群（高加索人）的RCC风险呈正相关，而对于亚洲人则没有。G等位基因和GG基因型与RCC在总体人群，高加索人和亚洲人中的易感性无关。G等位基因与亚洲人总体人群中PCa敏感性呈负相关，而对白种人而言则不然。GG基因型与亚洲人对PCa的敏感性呈负相关，但对总体人群和高加索人则不相关。HIF1α1790G / A AA基因型与白种人或亚洲人的总体人群中PCa的敏感性无关。HIF1α1790G / A的AA基因型与总体人群和高加索人的RCC风险呈正相关。此外，G等位基因与总体人群（亚洲人）与前列腺癌易感性呈负相关，而GG基因型与亚洲人PCa易感性呈负相关。HIF1α1790G / A AA基因型与高加索人或亚洲人的总体人群中PCa的敏感性无关。HIF1α1790G / A的AA基因型与总体人群和高加索人的RCC风险呈正相关。此外，G等位基因与总体人群（亚洲人）的前列腺癌易感性呈负相关，而GG基因型与亚洲人PCa的易感性呈负相关。HIF1α1790G / A AA基因型与高加索人或亚洲人的总体人群中PCa的敏感性无关。HIF1α1790G / A的AA基因型与总体人群和高加索人的RCC风险呈正相关。此外，G等位基因与总体人群（亚洲人）的前列腺癌易感性呈负相关，而GG基因型与亚洲人PCa的易感性呈负相关。