Various studies have investigated the relationship between the polymorphism, rs2596542, in the promoter of the major histocompatibility complex class I-related gene A (MICA) gene with susceptibility to hepatitis B virus (HBV)/ hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC); however, the results are inconclusive. This meta-analysis was conducted to investigate the relationship between rs2596542 and HCV/HBV-induced HCC. Three electronic scientific publication databases (MEDLINE, Web of Science, and Embase) were screened using specific search terms and relevant literature identified using literature traceability methods. Selected publications were evaluated according to the inclusion and exclusion criteria, and 11 articles were included in the study. Effect size information (odds ratio [OR] and corresponding 95% confidence interval [CI]) were obtained following quality assessment and data extraction from the included publications, and a meta-analysis conducted. A total of 11 publications were included in the study, including 4582 patients with HCC and 21,095 non-HCC patients. TT genotype at rs2596542 was a risk factor for the development of HCC in patients with HCV/HBV infection (OR = 1.248, 95% CI: 1.040–1.499, P = 0.017), particularly those with HCV infection (OR = 1.326, 95% CI: 1.101–1.599, P = 0.003) and Asians (OR = 1.273, 95% CI: 1.002–1.618, P = 0.048), or when the control group was patients with chronic hepatitis C (CHC) (OR = 1.506, 95% CI: 1.172–1.936, P = 0.001). The findings of this meta-analysis suggest that the rs2596542 variant in the MICA promoter region may affect MICA and soluble MICA (sMICA) protein expression, thereby influencing physiological vulnerability to HCC cells and the development of HCC. These data provide a theoretical basis for the diagnosis and treatment of patients with HCC and viral hepatitis infection.

中文翻译：

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MICA基因启动子中的rs2596542多态性与HBV / HCV感染引起的肝细胞癌的关系：荟萃分析

各种研究调查了主要组织相容性复合物I类相关基因A（MICA）基因启动子中的多态性rs2596542与乙型肝炎病毒（HBV）/丙型肝炎病毒（HCV）诱发的肝细胞癌的易感性之间的关系（HCC）；但是，结果尚无定论。进行这项荟萃分析，以研究rs2596542与HCV / HBV诱导的HCC之间的关系。使用特定搜索词和使用文献可追溯性方法识别的相关文献筛选了三个电子科学出版物数据库（MEDLINE，Web of Science和Embase）。根据纳入和排除标准对选定的出版物进行了评估，研究中纳入了11篇文章。在从纳入的出版物中进行质量评估和数据提取后，获得效应量信息（几率[OR]和相应的95％置信区间[CI]），并进行了荟萃分析。该研究共纳入11篇出版物，包括4582例HCC患者和21,095例非HCC患者。rs2596542的TT基因型是HCV / HBV感染患者（OR = 1.248，95％CI：1.040-1.499，P = 0.017）发展为HCC的危险因素，尤其是那些HCV感染患者（OR = 1.326，95％） CI：1.101–1.599，P = 0.003）和亚洲人（OR = 1.273，95％CI：1.002–1.618，P = 0.048），或者对照组为慢性丙型肝炎（CHC）患者（OR = 1.506，95） ％CI：1.172–1.936，P = 0.001）。这项荟萃分析的结果表明，MICA启动子区域中的rs2596542变异体可能会影响MICA和可溶性MICA（sMICA）蛋白表达，从而影响对HCC细胞的生理脆弱性和HCC的发育。这些数据为肝癌和病毒性肝炎感染的诊断和治疗提供了理论依据。