BACKGROUND Several studies have focused on the relationship between MMP-8 variants and cancer risk, but they have been unsuccessful in drawing reliable conclusions. METHODS We employed odds ratio (OR) together with 95% confidence interval (CI) to assess the correlation between MMP-8 C-799 T, Lys460Thr, and Lys87Glu polymorphisms and cancer risk. We further employed in silico tools to evaluate the effect of MMP-8 expression on cancer susceptibility and overall survival time. RESULTS A total of 8140 patients with malignant carcinoma and 10,529 healthy individuals (control) were enrolled. Overall, the analysis showed that the relationship between three MMP-8 variants and cancer susceptibility was not significant (allelic contrast, C-799 T: OR = 0.98, 95% CI = 0.92-1.04, Pheterogeneity = 0.068; Lys460Thr: OR = 0.94, 95% CI = 0.67-1.32, Pheterogeneity = 0.905; Lys87Glu: OR = 1.05, 95% CI = 0.93-1.18, Pheterogeneity = 0.968). Similar results were observed in subgroup analysis by ethnicity, cancer type, and source of control. In silico analysis indicated that MMP-8 expression was elevated in bladder cancer tissue compared to that in the control. However, both the higher and lower MMP-8 expression groups did not show an impact on the overall survival time of the patients. CONCLUSIONS MMP-8 C-799 T, Lys460Thr, and Lys87Glu variants are not participant with the susceptibility of cancer.

中文翻译：

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MMP-8 C-799 T，Lys460Thr和Lys87Glu变体与癌症风险无关。

背景技术一些研究集中在MMP-8变体与癌症风险之间的关系上，但是在得出可靠的结论方面还没有成功。方法我们采用比值比（OR）和95％置信区间（CI）来评估MMP-8 C-799 T，Lys460Thr和Lys87Glu多态性与癌症风险之间的相关性。我们进一步采用计算机工具评估MMP-8表达对癌症易感性和总生存时间的影响。结果共纳入8140例恶性肿瘤患者和10,529名健康个体（对照组）。总体而言，分析表明三种MMP-8变体与癌症易感性之间的关系不显着（等位基因对比，C-799 T：OR = 0.98,95％CI = 0.92-1.04，光生性= 0.068; Lys460Thr：OR = 0.94 ，95％CI = 0.67-1.32，光生度= 0.905; Lys87Glu：OR = 1.05，95％CI = 0.93-1.18，光生性= 0.968）。在按种族，癌症类型和控制源进行的亚组分析中，观察到了相似的结果。计算机分析表明，与对照相比，膀胱癌组织中MMP-8表达升高。但是，较高和较低的MMP-8表达组均未显示出对患者总生存时间的影响。结论MMP-8 C-799 T，Lys460Thr和Lys87Glu变体不参与癌症的易感性。但是，较高和较低的MMP-8表达组均未显示出对患者总生存时间的影响。结论MMP-8 C-799 T，Lys460Thr和Lys87Glu变体不参与癌症的易感性。但是，较高和较低的MMP-8表达组均未显示出对患者总生存时间的影响。结论MMP-8 C-799 T，Lys460Thr和Lys87Glu变体不参与癌症的易感性。