Little is known about the presence of specific autoantibodies in ankylosing spondylitis (AS), an immune-mediated inflammatory disease. The object of this study was to explore potential autoantibody profiles in AS patients. Levels of anti-SIRT1 autoantibodies were significantly higher in AS (P < 0.001) and psoriatic arthritis (PsA) (P < 0.01) patients but not rheumatoid arthritis (RA) patients compared with healthy controls. Additionally, titers of anti-NAD-dependent protein deacetylase sirtuin-1(SIRT1) antibodies were significantly higher in AS patients than in RA (P < 0.05) and PsA (P < 0.05) patients. Moreover, levels of anti-SIRT1 (P < 0.001) antibodies were significantly higher during the first year in patients with hip joint involvement. The anti-SIRT1 antibody positivity rate was 18.9% in AS patients. Our findings indicate that anti-SIRT1 autoantibodies may serve as a marker for diagnosing AS and predicting hip joint involvement at an early stage.

中文翻译：

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抗SIRT1自身抗体在强直性脊柱炎中升高：潜在的疾病生物标志物

对于强直性脊柱炎（AS）（一种免疫介导的炎性疾病）中特定自身抗体的存在知之甚少。这项研究的目的是探讨AS患者中潜在的自身抗体谱。与健康对照组相比，AS（P <0.001）和银屑病关节炎（PsA）（P <0.01）患者的抗SIRT1自身抗体水平显着更高，而类风湿关节炎（RA）患者则没有。此外，AS患者中抗NAD依赖性蛋白脱乙酰基酶sirtuin-1（SIRT1）抗体的滴度显着高于RA患者（P <0.05）和PsA（P <0.05）。此外，髋关节受累患者在第一年中的抗SIRT1（P <0.001）抗体水平显着更高。AS患者的抗SIRT1抗体阳性率为18.9％。