Genetic factors increase the risk of irritable bowel syndrome (IBS). Analysis of single nucleotide polymorphisms (SNPs) has been used in IBS patients, but the findings are inconsistent. The goal of this review was to synthesize all the published SNPs studies of IBS through meta-analysis to objectively evaluate the relevance of SNPs to IBS risks. IBS - related polymorphisms studies from 2000 to 2018 were searched. Pooled odds ratios with a 95% confidence interval for each SNP were evaluated through five genetic models. Ethnicity, ROME criteria and IBS subtypes were defined for subgroup analyze. Ten relevant genes were evaluated. SNPs rs4263839 and rs6478108 of TNFSF15 associated with an increased risk of IBS; IL6 rs1800795 increased the risk for Caucasian IBS patients which diagnosed by Rome III criteria; and IL23R rs11465804 increased the risk for IBS-C patients. IL10 rs1800896 GG genotype associated with a decreased risk of IBS. No evidence supported the association of GNβ3 rs5443, TNFα rs1800629, and IL10 rs1800871 to IBS in this study. This meta-analysis presents an in-depth overview for IBS SNPs analysis. It was confirmed that polymorphisms of TNFSF15 associated with increased IBS risk, while IL10 rs1800896 associated with decreased IBS risk. It might offer some insights into polymorphisms of inflammation factors which might affect IBS susceptibility. Moreover, the analysis also emphasizes the importance of diagnostic criteria and phenotype homogeneity in IBS genetic studies.

中文翻译：

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肠易激综合征的候选单核苷酸多态性：系统评价和荟萃分析

遗传因素会增加肠易激综合症（IBS）的风险。IBS患者已使用单核苷酸多态性（SNP）分析，但发现不一致。这篇综述的目的是通过荟萃分析综合所有已发表的IBS SNP研究，以客观评估SNP与IBS风险的相关性。检索了2000年至2018年IBS相关的多态性研究。通过五个遗传模型评估了每个SNP具有95％置信区间的合并优势比。定义种族，ROME标准和IBS亚型以进行亚组分析。评价了十个相关基因。TNFSF15的SNP rs4263839和rs6478108与IBS风险增加相关；IL6 rs1800795增加了根据罗马三世标准诊断出的白种人IBS患者的风险；IL23R rs11465804和IBS-C患者的风险增加。IL10 rs1800896 GG基因型与IBS风险降低相关。在本研究中，没有证据支持GNβ3rs5443，TNFαrs1800629和IL10 rs1800871与IBS的关联。这项荟萃分析提供了IBS SNP分析的深入概述。证实了TNFSF15的多态性与IBS风险增加有关，而IL10 rs1800896与IBS风险降低有关。它可能提供一些炎症因素多态性的见解，这些因素可能会影响IBS的易感性。此外，分析还强调了IBS基因研究中诊断标准和表型同质性的重要性。在本研究中，IL10 rs1800871属于IBS。这项荟萃分析提供了IBS SNP分析的深入概述。证实了TNFSF15的多态性与IBS风险增加有关，而IL10 rs1800896与IBS风险降低有关。它可能提供一些炎症因素多态性的见解，这些因素可能会影响IBS的易感性。此外，分析还强调了IBS基因研究中诊断标准和表型同质性的重要性。在本研究中，IL10 rs1800871属于IBS。这项荟萃分析提供了IBS SNP分析的深入概述。证实了TNFSF15的多态性与IBS风险增加有关，而IL10 rs1800896与IBS风险降低有关。它可能提供一些炎症因素多态性的见解，这些因素可能会影响IBS的易感性。此外，分析还强调了IBS基因研究中诊断标准和表型同质性的重要性。