BACKGROUND Subjects with prediabetes are at increased risk of future T2DM and cardiovascular disease (CVD) compared to NGT individuals. The OGTT (FPG = 100-125 and 2 h-PG = 140-199 mg/dl) and HbA1c 5.7-6.4% have been used to diagnose subjects with prediabetes. In the present study, we compared the ability of the OGTT and HbA1c to identify Qatari subjects with prediabetes. METHODS Four hundred forty six subjects without a history of T2DM received 75-g OGTT and measurement of HbA1c. The incidence of prediabetes in this cohort according to OGTT criteria was compared to that of HbA1c criteria. RESULTS The agreement between the OGTT and HbA1c in identifying subjects with prediabetes in Qatari subjects was poor, though significant (k = 015, p < 0.0001). Only 56% of participants had prediabetes or NGT according to OGTT and HbA1c. The disagreement between OGTT and HbA1c in diagnosing prediabetes was primarily due to low sensitivity of HbA1c. Moreover, subjects with prediabetes diagnosed with the OGTT have more severe metabolic profile than prediabetic subjects diagnosed with HbA1c. Lastly, more subjects with the metabolic syndrome were identified with OGTT (60%) criteria than with the HbA1c (49%), p < 0.0001. CONCLUSION These results demonstrate subjects with prediabetes diagnosed with OGTT have more severe metabolic risk than those diagnosed with HbA1c, and more likely to have greater risk of progression to T2DM.

中文翻译：

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糖化血红蛋白与口服葡萄糖耐量试验在识别卡塔尔人群中糖尿病前期受试者中的比较。


背景与 NGT 个体相比，患有糖尿病前期的受试者未来患 T2DM 和心血管疾病 (CVD) 的风险增加。 OGTT（FPG = 100-125 和 2 h-PG = 140-199 mg/dl）和 HbA1c 5.7-6.4% 已用于诊断糖尿病前期受试者。在本研究中，我们比较了 OGTT 和 HbA1c 识别卡塔尔受试者患有糖尿病前期的能力。方法 446 名无 T2DM 病史的受试者接受 75 g OGTT 和 HbA1c 测量。将根据 OGTT 标准与 HbA1c 标准计算的该队列中糖尿病前期的发生率进行比较。结果 OGTT 和 HbA1c 在识别卡塔尔受试者中的糖尿病前期受试者方面的一致性较差，但很显着 (k = 015, p < 0.0001)。根据 OGTT 和 HbA1c，只有 56% 的参与者患有糖尿病前期或 NGT。 OGTT 和 HbA1c 在诊断糖尿病前期方面的分歧主要是由于 HbA1c 的敏感性较低。此外，诊断为 OGTT 的糖尿病前期受试者比诊断为 HbA1c 的糖尿病前期受试者具有更严重的代谢特征。最后，采用 OGTT (60%) 标准确定的代谢综合征受试者多于采用 HbA1c (49%) 标准的受试者，p < 0.0001。结论 这些结果表明，诊断为 OGTT 的糖尿病前期受试者比诊断为 HbA1c 的受试者具有更严重的代谢风险，并且更有可能有更大的进展为 T2DM 的风险。