BACKGROUND Hypertriglyceridemia is often observed as the result of lipid abnormality and frequently associated with other lipid and metabolic disorders. Aggravation of hypertriglyceridemia is caused by various conditions. However, severe hypertriglyceridemia is usually induced by an addition of some secondary clinical conditions such as uncontrolled type 2 diabetes mellitus (T2DM) and obesity with insulin resistance. CASE PRESENTATION A 40-year-old man with 4-year history of dyslipidemia and T2DM visited after his interruption of therapy for about 1.5 years. His past history was acute pancreatitis. His life style was markedly disturbed, and he had a lot of risk factors for hypertriglyceridemia. Surprisingly, his serum triglyceride level was as high as 16,900 mg/dL. His aggravation and remission of hypertriglyceridemia were closely associated with the alteration of RLP-cholesterol levels in dyslipidemia and glycoalbumin and ketone body levels in T2DM. CONCLUSION We report very severe hypertriglyceridemia, which seemed to be caused by markedly disturbed life style and poorly controlled T2DM. Total therapy with diet and drug for each disease is very important for the improvement of very severe hypertriglyceridemia. This case report suggests that very severe hypertriglyceridemia alone does not necessarily bring out acute pancreatitis, although it is very important to check pancreatitis markers in such a situation.

中文翻译：

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生活方式不佳且血糖控制不良且急性胰腺炎未复发的受试者中的严重高甘油三酯血症：一例病例报告。

背景技术高甘油三酸酯血症通常是由于脂质异常而观察到的，并且经常与其他脂质和代谢异常有关。高甘油三酯血症的加重是由多种情况引起的。但是，严重的高甘油三酯血症通常是由一些继发性临床疾病（如不受控制的2型糖尿病（T2DM）和具有胰岛素抵抗的肥胖症）引起的。病例介绍一名40岁的具有4年血脂异常和T2DM病史的男子在中断治疗约1.5年后就诊。他过去的病史是急性胰腺炎。他的生活方式明显受到干扰，并且他有很多高甘油三酯血症的危险因素。令人惊讶的是，他的血清甘油三酸酯水平高达16,900 mg / dL。他的高甘油三酯血症的加重和缓解与血脂异常中RLP胆固醇水平的改变以及T2DM中糖蛋白和酮体水平的改变密切相关。结论我们报告了非常严重的高甘油三酯血症，这似乎是由于生活方式明显受到干扰和T2DM控制不良所致。饮食和药物对每种疾病的全面治疗对于改善非常严重的高甘油三酯血症非常重要。该病例报告表明，尽管在这种情况下检查胰腺炎标志物非常重要，但仅是非常严重的高甘油三酸酯血症并不一定会导致急性胰腺炎。这似乎是由于生活方式受到明显干扰以及T2DM的控制不佳所致。饮食和药物对每种疾病的全面治疗对于改善非常严重的高甘油三酯血症非常重要。该病例报告表明，尽管在这种情况下检查胰腺炎标志物非常重要，但仅是非常严重的高甘油三酸酯血症并不一定会导致急性胰腺炎。这似乎是由于生活方式受到明显干扰以及T2DM的控制不佳所致。饮食和药物对每种疾病的全面治疗对于改善非常严重的高甘油三酯血症非常重要。该病例报告表明，尽管在这种情况下检查胰腺炎标志物非常重要，但仅是非常严重的高甘油三酸酯血症并不一定会导致急性胰腺炎。