To determine the association between maternal cardiometabolic and inflammatory markers with measures of fetal biometry and adiposity. Women included in this exploratory analysis were randomised to the ‘Standard Care’ group (N = 911) from the LIMIT randomised trial involving a total of 2212 pregnant women who were overweight or obese (ACTRN12607000161426, Date of registration 9/03/2007, prospectively registered). Fetal biometry including abdominal circumference (AC), estimated fetal weight (EFW), and adiposity measurements (mid-thigh fat mass, subscapular fat mass, abdominal fat mass) were obtained from ultrasound assessments at 28 and 36 weeks’ gestation. Maternal markers included C reactive protein (CRP), leptin and adiponectin concentrations, measured at 28 and 36 weeks’ gestation and fasting triglycerides and glucose concentrations measured at 28 weeks’ gestation. There were negative associations identified between maternal serum adiponectin and fetal ultrasound markers of biometry and adiposity. After adjusting for confounders, a 1-unit increase in log Adiponectin was associated with a reduction in the mean AC z score [− 0.21 (− 0.35, − 0.07), P = 0.004] and EFW [− 0.23 (− 0.37, − 0.10), P < 0.001] at 28 weeks gestation. Similarly, a 1-unit increase in log Adiponectin was association with a reduction in the mean AC z score [− 0.30 (− 0.46, − 0.13), P < 0.001] and EFW [− 0.24 (− 0.38, − 0.10), P < 0.001] at 36 weeks gestation. There were no consistent associations between maternal cardiometabolic and inflammatory markers with measurements of fetal adiposity. Adiponectin concentrations are associated with measures of fetal growth. Our findings contribute to further understanding of fetal growth in the setting of women who are overweight or obesity.

中文翻译：

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孕妇心脏代谢指标与胎儿生长有关：LIMIT随机试验的二次探索性分析

为了确定孕妇的心脏代谢和炎症标志物与胎儿生物特征和肥胖的关系。该探索性分析中的女性从LIMIT随机试验中随机分为“标准护理”组（N = 911），该试验涉及总共2212名超重或肥胖的孕妇（ACTRN12607000161426，注册日期9/03/2007，前瞻性）挂号的）。胎儿生物学包括腹围（AC），估计胎儿体重（EFW）和肥胖测量（大腿中段脂肪，肩s下脂肪段，腹部脂肪段）是在妊娠28周和36周时通过超声评估获得的。母体标志物包括C反应蛋白（CRP），瘦素和脂联素浓度，在妊娠28和36周时测量，空腹甘油三酯和在妊娠28周时测量的葡萄糖浓度。孕妇血清脂联素与胎儿超声检查的生物特征和肥胖之间存在负相关关系。调整混杂因素后，对数脂联素增加1个单位会导致平均AC z得分降低[-0.21（-0.35，-0.07），P = 0.004]和EFW [-0.23（-0.37，-0.10） ），在妊娠28周时P <0.001]。类似地，log Adiponectin增加1个单位与平均AC z得分降低[-0.30（-0.46，-0.13），P <0.001]和EFW [-0.24（-0.38，-0.10），P相关<0.001]在妊娠36周时。孕妇的心脏代谢和炎症指标与胎儿肥胖的测量之间没有一致的关联。脂联素浓度与胎儿生长的测量有关。我们的发现有助于进一步了解超重或肥胖妇女的胎儿发育情况。