Adhesions represent a major burden in clinical practice, particularly following abdominal, intrauterine, pericardial and tendon surgical procedures. Adhesions are initiated by a disruption in the epithelial or mesothelial layer of tissue, which leads to fibrin adhesion sites due to the downregulation of fibrinolytic activity and an increase in fibrin deposition. Hence, the metabolic events involved in tissue healing, coagulation, inflammation, fibrinolysis and angiogenesis play a pivotal role in adhesion formation. Understanding these events, their interactions and their influence on the development of post-surgical adhesion is crucial for the development of effective therapies to prevent them. Mechanical barriers, antiadhesive agents and combination thereof are customarily used in the battle against adhesions. Although these systems seem to be effective at reducing adhesions in clinical procedures, their prevention remains still elusive, imposing the need for new antiadhesive strategies.

中文翻译：

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对抗粘连：从理解到预防。

粘附是临床实践中的主要负担，尤其是在腹部，子宫内，心包和肌腱外科手术之后。粘附是由组织上皮或间皮层的破坏引起的，这由于血纤蛋白溶解活性的下调和血纤蛋白沉积的增加而导致血纤蛋白附着位点。因此，涉及组织愈合，凝血，炎症，纤维蛋白溶解和血管生成的代谢事件在粘附形成中起关键作用。了解这些事件，它们之间的相互作用以及它们对手术后粘连发展的影响，对于开发预防这些事件的有效疗法至关重要。机械屏障，抗粘剂及其组合通常用于抵抗粘着力。