A growing need exists for neuroscience platforms that can perform simultaneous chronic recording and stimulation of neural tissue in animal models in a telemetry-controlled fashion with signal processing for analysis of the chronic recording data and external triggering capability. We describe the system design, testing, evaluation, and implementation of a wireless simultaneous stimulation-and-recording device (SRD) for modulating cortical circuits in physiologically identified sites in primary somatosensory (SI) cortex in awake-behaving and freely-moving rats. The SRD was developed using low-cost electronic components and open-source software. The function of the SRD was assessed by bench and in-vivo testing. The SRD recorded spontaneous spiking and bursting neuronal activity, evoked responses to programmed intracortical microstimulation (ICMS) delivered internally by the SRD, and evoked responses to external peripheral forelimb stimulation. The SRD is capable of wireless stimulation and recording on a predetermined schedule or can be wirelessly synchronized with external input as would be required in behavioral testing prior to, during, and following ICMS.

中文翻译：

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遥测控制的同步刺激和记录装置 (SRD) 用于研究大鼠初级体感 (SI) 皮层的大脑半球间皮层回路。

对神经科学平台的需求日益增长，该平台可以以遥测控制的方式同时对动物模型中的神经组织进行慢性记录和刺激，并通过信号处理来分析慢性记录数据和外部触发能力。我们描述了无线同步刺激和记录设备 (SRD) 的系统设计、测试、评估和实施，用于调节清醒行为和自由活动大鼠初级体感 (SI) 皮层生理识别部位的皮层回路。SRD 是使用低成本电子元件和开源软件开发的。SRD 的功能通过台架和体内测试进行评估。SRD 记录了自发的尖峰和爆发神经元活动，诱发对 SRD 内部传递的程序化皮质内微刺激 (ICMS) 的反应，并诱发对外周前肢刺激的反应。SRD 能够按照预定的时间表进行无线刺激和记录，或者可以与外部输入无线同步，这在 ICMS 之前、期间和之后的行为测试中需要。