Associations between allergic disease and puberty amongst females have been widely studied. However, this association has received less attention in multigenerational populations. To this end, we sought to examine maternal allergic disease status ever, and daughters’ menarche. In a cohort of children born in 1995, in Manitoba, Canada, we considered maternal allergic disease ever to daughters’ age 7–8 years, and daughters’ menarche at ages 12–14 years. We included all participants for whom we had information on both the exposure and the outcome of those eligible. Data were analysed using descriptive statistics and logistic regression, with adjustment for confounding variables. Overall, the prevalences of maternal allergic diseases were 28.6% for asthma 18.8% for food allergy, 27.3% for eczema and 45.5% for rhinitis. By age 12–14 years, 41.6% (64/159) girls had reached menarche. Maternal food allergy was significantly associated with daughters’ menarche (OR 4.39, 95% CI 1.51–12.73), whereas no association was found for maternal asthma, eczema or rhinitis. With consideration to comorbid disease, a combination of maternal asthma + food allergy was associated with daughters’ menarche by age 12–14 years (OR 6.41; 95% CI 1.32–31.01). Maternal food allergy ever is associated with daughters’ menarche by age 12–14 years.

中文翻译：

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母亲食物过敏与女儿青春期初潮有关

过敏性疾病与女性青春期之间的关系已被广泛研究。然而，这种关联在多代人群中受到的关注较少。为此，我们试图检查母亲过敏性疾病的状况，以及女儿的初潮。在 1995 年出生于加拿大马尼托巴省的一组儿童中，我们认为母亲过敏性疾病一直持续到女儿 7-8 岁，女儿初潮在 12-14 岁。我们包括了所有参与者，我们有关于这些参与者的暴露和结果的信息。使用描述性统计和逻辑回归分析数据，并调整混杂变量。总体而言，母亲过敏性疾病的患病率为哮喘 28.6%、食物过敏 18.8%、湿疹 27.3% 和鼻炎 45.5%。按 12-14 岁，41 岁。6% (64/159) 的女孩达到初潮。母亲食物过敏与女儿的月经初潮显着相关（OR 4.39，95% CI 1.51-12.73），而母亲哮喘、湿疹或鼻炎没有发现相关性。考虑到合并症，母亲哮喘+食物过敏与女儿在 12-14 岁的初潮有关（OR 6.41；95% CI 1.32-31.01）。母亲食物过敏与 12-14 岁女儿的月经初潮有关。32–31.01)。母亲食物过敏与 12-14 岁女儿的月经初潮有关。32–31.01)。母亲食物过敏与 12-14 岁女儿的月经初潮有关。