To assess the safety and efficacy of an oral immunotherapy regimen in patients with allergy to lipid transfer proteins (LTPs). Prospective study of 24 patients allergic to LTP with positive skin test and a history of anaphylaxis. All patients underwent a desensitization protocol with commercial peach juice. Rising doses of peach juice were administered, starting with an initial dose of seven drops of a 1/1000 dilution and finishing with a dose of 5 ml at visit 17. At visit 18, all patients performed an open challenge with whole juice at a cumulative dose of 200 ml. All adverse reactions occurring during the administration of the different doses were recorded. Levels of rPru p 3 in the juice were quantified. There were no severe reactions during the desensitization process in the 24 patients. Seven patients (29%) reported mild oral symptoms, and two patients (8%) had urticaria associated with co-factors (one due to exercise and another due to non-steroidal anti-inflammatory drugs). Nineteen patients were able to swallow 5 ml of juice and five withdrew from the study. In two pregnant patients the final challenge was not performed. In all, 17/24 patients were able to consume 200 ml peach juice without developing symptoms. Oral immunotherapy with the regimen used in this study is an effective and safe short-term therapeutic option for patients with allergy to LTPs. Commercial peach juice appears to be suitable for this treatment.

中文翻译：

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对 LTP 过敏的患者使用桃汁进行口服免疫治疗

评估口服免疫治疗方案在对脂质转移蛋白 (LTP) 过敏的患者中的安全性和有效性。对 24 例对 LTP 过敏且皮试呈阳性且有过敏反应史的患者进行的前瞻性研究。所有患者都接受了商业桃汁脱敏方案。给予增加剂量的桃汁，从七滴 1/1000 稀释液的初始剂量开始，到第 17 次就诊时以 5 毫升的剂量结束。在第 18 次就诊时，所有患者都用全汁以累积剂量为 200 毫升。记录不同剂量给药期间发生的所有不良反应。对果汁中 rPru p 3 的水平进行了量化。24例患者在脱敏过程中均未出现严重反应。七名患者（29%）报告有轻微的口腔症状，两名患者（8%）患有与辅助因素相关的荨麻疹（一名是由于运动，另一名是由于非甾体类抗炎药）。19 名患者能够吞下 5 毫升果汁，其中 5 名退出了研究。在两名怀孕的患者中，没有进行最后的攻击。总共有 17/24 名患者能够饮用 200 毫升桃汁而不会出现症状。对于对 LTP 过敏的患者，采用本研究中使用的方案进行口服免疫治疗是一种有效且安全的短期治疗选择。商业桃汁似乎适合这种治疗。在两名怀孕的患者中，没有进行最后的攻击。总共有 17/24 名患者能够饮用 200 毫升桃汁而不会出现症状。对于对 LTP 过敏的患者，采用本研究中使用的方案进行口服免疫治疗是一种有效且安全的短期治疗选择。商业桃汁似乎适合这种治疗。在两名怀孕的患者中，没有进行最后的攻击。总共有 17/24 名患者能够饮用 200 毫升桃汁而不会出现症状。对于对 LTP 过敏的患者，采用本研究中使用的方案进行口服免疫治疗是一种有效且安全的短期治疗选择。商业桃汁似乎适合这种治疗。