Neuropathological follow-up of patients with Alzheimer's disease (AD) who participated in the first clinical trial of Amyloid-β 42 (Aβ42) immunization (AN1792, Elan Pharmaceuticals) has shown that immunization can induce removal of Aβ42 and Aβ40 from plaques, whereas analysis of the cerebral vessels has shown increased levels of these Aβ peptides in cerebral amyloid angiopathy (CAA). Aβ43 has been less frequently studied in AD, but its aggregation propensity and neurotoxic properties suggest it may have an important pathogenic role. In the current study we show by using immunohistochemistry that in unimmunized AD patients Aβ43 is a frequent constituent of plaques (6.0% immunostained area), similar to Aβ42 (3.9% immunostained area). Aβ43 immunostained area was significantly higher than that of Aβ40 (2.3%, p = 0.006). In addition, we show that Aβ43 is only a minor component of CAA in both parenchymal vessels (1.5 Aβ43-positive vessels per cm2 cortex vs. 5.3 Aβ42-positive vessels, p = 0.03, and 6.2 Aβ40-positive vessels, p = 0.045) and leptomeningeal vessels (5.6% Aβ43-positive vessels vs. 17.3% Aβ42-positive vessels, p = 0.007, and 27.4% Aβ40-positive vessels, p = 0.003). Furthermore, we have shown that Aβ43 is cleared from plaques after Aβ immunotherapy, similar to Aβ42 and Aβ40. Cerebrovascular Aβ43 levels did not change after immunotherapy.

中文翻译：

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Aβ43 在人类阿尔茨海默病中：主动 Aβ42 免疫的影响。

对参与淀粉样蛋白 β 42 (Aβ42) 免疫（AN1792，Elan Pharmaceuticals）的首次临床试验的阿尔茨海默病 (AD) 患者的神经病理学随访表明，免疫可诱导从斑块中去除 Aβ42 和 Aβ40，而分析在脑淀粉样血管病 (CAA) 中，脑血管中的这些 Aβ 肽水平升高。Aβ43 在 AD 中的研究较少，但其聚集倾向和神经毒性表明它可能具有重要的致病作用。在目前的研究中，我们通过使用免疫组织化学表明，在未免疫的 AD 患者中，Aβ43 是斑块的常见成分（6.0% 免疫染色面积），类似于 Aβ42（3.9% 免疫染色面积）。Aβ43 免疫染色面积显着高于 Aβ40（2.3%，p = 0.006）。此外，我们表明，Aβ43 在两个实质血管（每平方厘米皮质 1.5 个 Aβ43 阳性血管与 5.3 个 Aβ42 阳性血管，p = 0.03 和 6.2 个 Aβ40 阳性血管，p = 0.045）和软脑膜血管中只是 CAA 的次要成分（5.6% Aβ43 阳性血管对比 17.3% Aβ42 阳性血管，p = 0.007，27.4% Aβ40 阳性血管，p = 0.003）。此外，我们已经表明 Aβ43 在 Aβ 免疫治疗后从斑块中清除，类似于 Aβ42 和 Aβ40。免疫治疗后脑血管Aβ43水平没有变化。此外，我们已经表明 Aβ43 在 Aβ 免疫治疗后从斑块中清除，类似于 Aβ42 和 Aβ40。免疫治疗后脑血管Aβ43水平没有变化。此外，我们已经证明 Aβ43 在 Aβ 免疫治疗后从斑块中清除，类似于 Aβ42 和 Aβ40。免疫治疗后脑血管Aβ43水平没有变化。