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TGF-β Signaling Promotes Tissue Formation during Cardiac Valve Regeneration in Adult Zebrafish.
Developmental Cell ( IF 10.7 ) Pub Date : 2019-11-27 , DOI: 10.1016/j.devcel.2019.10.027 Anabela Bensimon-Brito 1 , Srinath Ramkumar 1 , Giulia L M Boezio 1 , Stefan Guenther 2 , Carsten Kuenne 3 , Christian S M Helker 1 , Héctor Sánchez-Iranzo 4 , Dijana Iloska 5 , Janett Piesker 6 , Soni Pullamsetti 5 , Nadia Mercader 7 , Dimitris Beis 8 , Didier Y R Stainier 1
Developmental Cell ( IF 10.7 ) Pub Date : 2019-11-27 , DOI: 10.1016/j.devcel.2019.10.027 Anabela Bensimon-Brito 1 , Srinath Ramkumar 1 , Giulia L M Boezio 1 , Stefan Guenther 2 , Carsten Kuenne 3 , Christian S M Helker 1 , Héctor Sánchez-Iranzo 4 , Dijana Iloska 5 , Janett Piesker 6 , Soni Pullamsetti 5 , Nadia Mercader 7 , Dimitris Beis 8 , Didier Y R Stainier 1
Affiliation
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Cardiac valve disease can lead to severe cardiac dysfunction and is thus a frequent cause of morbidity and mortality. Its main treatment is valve replacement, which is currently greatly limited by the poor recellularization and tissue formation potential of the implanted valves. As we still lack suitable animal models to identify modulators of these processes, here we used adult zebrafish and found that, upon valve decellularization, they initiate a rapid regenerative program that leads to the formation of new functional valves. After injury, endothelial and kidney marrow-derived cells undergo cell cycle re-entry and differentiate into new extracellular matrix-secreting valve cells. The TGF-β signaling pathway promotes the regenerative process by enhancing progenitor cell proliferation as well as valve cell differentiation. These findings reveal a key role for TGF-β signaling in cardiac valve regeneration and establish the zebrafish as a model to identify and test factors promoting cardiac valve recellularization and growth.
中文翻译：
TGF-β信号在成年斑马鱼的心脏瓣膜再生过程中促进组织形成。
心脏瓣膜疾病可导致严重的心脏功能障碍，因此是发病率和死亡率的常见原因。它的主要治疗方法是瓣膜置换术，目前，这种方法受到植入瓣膜的不良再细胞化和组织形成潜能的极大限制。由于我们仍然缺乏合适的动物模型来识别这些过程的调控因子，因此我们在这里使用了成年斑马鱼，并发现在瓣膜脱细胞后，它们会启动快速的再生程序，从而导致形成新的功能性瓣膜。损伤后，内皮细胞和肾源于骨髓的细胞经历细胞周期再进入，并分化成新的分泌细胞外基质的瓣膜细胞。TGF-β信号传导途径通过增强祖细胞增殖以及瓣膜细胞分化来促进再生过程。
更新日期：2019-11-28
中文翻译：
TGF-β信号在成年斑马鱼的心脏瓣膜再生过程中促进组织形成。
心脏瓣膜疾病可导致严重的心脏功能障碍，因此是发病率和死亡率的常见原因。它的主要治疗方法是瓣膜置换术，目前，这种方法受到植入瓣膜的不良再细胞化和组织形成潜能的极大限制。由于我们仍然缺乏合适的动物模型来识别这些过程的调控因子，因此我们在这里使用了成年斑马鱼，并发现在瓣膜脱细胞后，它们会启动快速的再生程序，从而导致形成新的功能性瓣膜。损伤后，内皮细胞和肾源于骨髓的细胞经历细胞周期再进入，并分化成新的分泌细胞外基质的瓣膜细胞。TGF-β信号传导途径通过增强祖细胞增殖以及瓣膜细胞分化来促进再生过程。
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