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Ambient mass spectrometry for the molecular diagnosis of lung cancer.
Analyst ( IF 3.6 ) Pub Date : 2019-11-27 , DOI: 10.1039/c9an01365b
Haiyan Lu 1 , Hua Zhang , Yiping Wei , Huanwen Chen
Affiliation  

Lung cancer is one of the most common malignancies and the leading cause of cancer-related death worldwide. Among the technologies suitable for the rapid and accurate molecular diagnosis of lung cancer, ambient mass spectrometry (AMS) has gained increasing interest as it allows the direct profiling of molecular information from various biological samples (e.g., tissue, serum, urine and sputum) in real-time and with minimal or no sample pretreatment. This minireview summarizes the applications of AMS in lung cancer studies (including tissue molecular identification, the discovery of potential biomarkers, and surgical margin assessment), and discusses the challenges and perspectives of AMS in the clinical precision molecular diagnosis of lung cancer.

中文翻译:

环境质谱法用于肺癌的分子诊断。

肺癌是最常见的恶性肿瘤之一,也是全球范围内与癌症相关的死亡的主要原因。在适合快速,准确诊断肺癌分子的技术中,环境质谱(AMS)引起了越来越多的关注,因为它可以直接分析来自各种生物样品(例如组织,血清,尿液和痰液)的分子信息。实时且无需进行最少的样品预处理。这份小型综述总结了AMS在肺癌研究中的应用(包括组织分子鉴定,潜在生物标志物的发现和手术切缘评估),并讨论了AMS在肺癌临床精确分子诊断中的挑战和前景。
更新日期:2019-11-27
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