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Multifunctional gold nanoparticles as smart nanovehicles with enhanced tumour-targeting abilities for intracellular pH mapping and in vivo MR/fluorescence imaging.
Nanoscale ( IF 5.8 ) Pub Date : 2020-01-08 , DOI: 10.1039/c9nr06347a Kang-Kang Yu 1 , Kun Li , Chun-Yan Lu , Yong-Mei Xie , Yan-Hong Liu , Qian Zhou , Jin-Ku Bao , Xiao-Qi Yu
Nanoscale ( IF 5.8 ) Pub Date : 2020-01-08 , DOI: 10.1039/c9nr06347a Kang-Kang Yu 1 , Kun Li , Chun-Yan Lu , Yong-Mei Xie , Yan-Hong Liu , Qian Zhou , Jin-Ku Bao , Xiao-Qi Yu
Affiliation
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A number of multimodal agents have been developed for tumour imaging and diagnosis, but most of them cannot be used to study the detailed physiological or pathological changes in living cells at the same time. Herein, a series of pH-responsive magnetic resonance and fluorescence imaging (MRI/FI) dual-modal "nanovehicles" are developed and tested. These new dual-modal materials allow for intercellular pH sensing, and those with units that are dually sensitive towards both acidic and basic environments have the ability for intracellular pH mapping and can be used to quantify pH at the cellular level. In addition, detailed pH changes in organelles (including lysosomes and mitochondria) can be investigated at the same time. On the other hand, with the tumour-targeting peptide (cRGD)-modified dual-modal nanovehicles, in vivo tumour MR and fluorescence imaging, which is suitable for cancer diagnosis, can be achieved. Moreover, it has been proved that these materials can pass through the blood brain barrier (BBB). By combining the above mentioned promising properties, these novel multifunctional "nanovehicles" may provide a new method for studying the role of pH during cancer diagnosis and treatment.
中文翻译：
多功能金纳米颗粒作为智能纳米载体，具有增强的肿瘤靶向能力，可用于细胞内pH定位和体内MR /荧光成像。
已经开发出许多用于肿瘤成像和诊断的多峰性药物，但是它们中的大多数不能用于同时研究活细胞的详细生理或病理变化。在本文中，开发并测试了一系列pH响应磁共振和荧光成像（MRI / FI）双模态“ nanovehicles”。这些新的双峰材料可实现细胞间pH传感，而那些对酸性和碱性环境均具有双重敏感性的单元则具有细胞内pH映射功能，可用于在细胞水平上定量pH。另外，可以同时研究细胞器（包括溶酶体和线粒体）中pH的详细变化。另一方面，利用肿瘤靶向肽（cRGD）修饰的双峰纳米载体，可以实现适用于癌症诊断的体内肿瘤MR和荧光成像。此外，已证明这些材料可以穿过血脑屏障（BBB）。通过结合上述有前途的特性，这些新颖的多功能“ nanovehicles”可以为研究pH在癌症诊断和治疗中的作用提供一种新方法。
更新日期：2020-01-08
中文翻译：
多功能金纳米颗粒作为智能纳米载体，具有增强的肿瘤靶向能力，可用于细胞内pH定位和体内MR /荧光成像。
已经开发出许多用于肿瘤成像和诊断的多峰性药物，但是它们中的大多数不能用于同时研究活细胞的详细生理或病理变化。在本文中，开发并测试了一系列pH响应磁共振和荧光成像（MRI / FI）双模态“ nanovehicles”。这些新的双峰材料可实现细胞间pH传感，而那些对酸性和碱性环境均具有双重敏感性的单元则具有细胞内pH映射功能，可用于在细胞水平上定量pH。另外，可以同时研究细胞器（包括溶酶体和线粒体）中pH的详细变化。另一方面，利用肿瘤靶向肽（cRGD）修饰的双峰纳米载体，可以实现适用于癌症诊断的体内肿瘤MR和荧光成像。此外，已证明这些材料可以穿过血脑屏障（BBB）。通过结合上述有前途的特性，这些新颖的多功能“ nanovehicles”可以为研究pH在癌症诊断和治疗中的作用提供一种新方法。
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