Biological motion is a powerful perceptual cue that can reveal important information about the inner state of an individual. Activation of inflammatory processes likely leads to changes in gait, posture, and mobility patterns, but the specific characteristics of inflammation-related biological motion have not been characterized. The aim of this study was to determine the effect of inflammation on gait and motion in humans. Systemic inflammation was induced in 19 healthy volunteers with an intravenous injection of lipopolysaccharide (2 ng/kg body weight). Biological motion parameters (walking speed, stride length and time, arm, leg, head, and shoulder angles) were assessed during a walking paradigm and the timed-up-and-go test. Cytokine concentrations, body temperature, and sickness symptoms were measured. During inflammation, compared to placebo, participants exhibited shorter, slower, and wider strides, less arm extension, less knee flexion, and a more downward-tilting head while walking. They were also slower and took shorter first steps in the timed-up-and-go test. Higher interleukin-6 concentrations, stronger sickness symptoms, and lower body temperature predicted the inflammation-related alterations in biological motion. These findings show that biological motion contains clear information about the inflammatory status of an individual, and may be used by peers or artificial intelligence to recognize that someone is sick or contagious.

中文翻译：

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人类炎症期间的生物运动

生物运动是一种强大的感知线索，可以揭示有关个人内部状态的重要信息。炎症过程的激活可能会导致步态、姿势和活动模式的变化，但与炎症相关的生物运动的具体特征尚未得到表征。这项研究的目的是确定炎症对人类步态和运动的影响。在 19 名健康志愿者中通过静脉注射脂多糖（2 ng/kg 体重）诱导全身炎症。生物运动参数（步行速度、步幅和时间、手臂、腿部、头部和肩部角度）在步行范式和计时起跑测试中进行评估。测量细胞因子浓度、体温和疾病症状。在炎症期间，与安慰剂相比，参与者表现出更短、更慢、更宽的步幅，更少的手臂伸展，更少的膝盖弯曲，以及走路时头部更向下倾斜。他们的速度也较慢，并且在计时开始测试中迈出了更短的第一步。较高的白细胞介素 6 浓度、较强的疾病症状和较低的体温预示着生物运动中与炎症相关的改变。这些发现表明，生物运动包含关于个体炎症状态的清晰信息，并且可能被同龄人或人工智能用来识别某人生病或传染。较高的白细胞介素 6 浓度、较强的疾病症状和较低的体温预示着生物运动中与炎症相关的改变。这些发现表明，生物运动包含关于个体炎症状态的清晰信息，并且可能被同龄人或人工智能用来识别某人生病或传染。较高的白细胞介素 6 浓度、较强的疾病症状和较低的体温预示着生物运动中与炎症相关的改变。这些发现表明，生物运动包含关于个体炎症状态的清晰信息，并且可能被同龄人或人工智能用来识别某人生病或传染。