BACKGROUND To date, clinical characteristics of the international severe asthma population are unknown. Inter-country comparisons are hindered by variable data collection within regional/national severe asthma registries. Our aim was to describe demographic and clinical characteristics of patients managed in severe asthma services in the USA, Europe, and Asia/Pacific region. METHODS The International Severe Asthma Registry (ISAR) retrospectively and prospectively collected data on severe asthma patients (≥18 years old), receiving GINA Step 5 treatment or remaining uncontrolled on GINA Step 4. Baseline demographic and clinical data were collected from the U.S., UK, South Korea, Italy, and the SAWD registry (including Australia, Singapore and New Zealand) from December 2014-December 2017. RESULTS 4,990 patients were included. Average age was 55.0 (SD: 15.9) years, and age at asthma onset 30.7 (SD: 17.7) years. Patients were predominantly female (59.3%), white (72.6%), had never smoked (60.5%) and were over-weight/obese (70.4%). 34.9% were on GINA Step 5. 57.2% had poorly controlled disease. 51.1% of patients were on regular intermittent OCS and 25.4% were on biologics (72.6% for those on GINA Step 5). Mean exacerbation rate was 1.7 (SD: 2.7) per year. Inter-country variation was observed in clinical characteristics, prescribed treatments and biomarker profiles. CONCLUSIONS Using a common dataset and definitions, this study is the first to describe severe asthma characteristics of a large cohort of patients included in multiple severe asthma registries, and to identify country differences. Whether these are related to underlying epidemiological, environmental factors, phenotype, asthma management systems, treatment access and/or cultural factors requires further study.

中文翻译：

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全球严重哮喘的特征：来自国际严重哮喘登记处 (ISAR) 的数据

背景迄今为止，国际重度哮喘人群的临床特征尚不清楚。区域/国家重度哮喘登记处的可变数据收集阻碍了国家间比较。我们的目的是描述在美国、欧洲和亚太地区接受严重哮喘服务管理的患者的人口统计学和临床​​特征。方法 国际重度哮喘登记处 (ISAR) 回顾性和前瞻性收集了接受 GINA Step 5 治疗或 GINA Step 4 未得到控制的重度哮喘患者（≥18 岁）的数据。基线人口统计学和临床​​数据来自美国、英国2014 年 12 月至 2017 年 12 月期间，韩国、意大利和 SAWD 登记处（包括澳大利亚、新加坡和新西兰）。 结果 包括 4,990 名患者。平均年龄为 55 岁。0 (SD: 15.9) 岁，哮喘发作年龄为 30.7 (SD: 17.7) 岁。患者主要是女性 (59.3%)、白人 (72.6%)、从不吸烟 (60.5%) 和超重/肥胖 (70.4%)。34.9% 处于 GINA 步骤 5。57.2% 的疾病控制不佳。51.1% 的患者接受定期间歇性 OCS，25.4% 接受生物制剂（72.6% 接受 GINA 步骤 5 的患者）。平均恶化率为每年 1.7 (SD: 2.7)。在临床特征、处方治疗和生物标志物谱中观察到国家间差异。结论 本研究使用通用数据集和定义，首次描述了包括在多个重度哮喘登记处的大量患者的重度哮喘特征，并确定了国家差异。这些是否与潜在的流行病学、环境因素、表型、