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The asarone-derived phenylpropanoids from the rhizome of Acorus calamus var. angustatus Besser
Phytochemistry ( IF 3.2 ) Pub Date : 2020-02-01 , DOI: 10.1016/j.phytochem.2019.112212 Yajun Bai 1 , Ying Sun 2 , Jing Xie 2 , Bin Li 2 , Yujun Bai 2 , Dongxu Zhang 3 , Jing Liang 4 , Chaoni Xiao 2 , Aiguo Zhong 5 , Yanjun Cao 2 , Xiaohui Zheng 2
Phytochemistry ( IF 3.2 ) Pub Date : 2020-02-01 , DOI: 10.1016/j.phytochem.2019.112212 Yajun Bai 1 , Ying Sun 2 , Jing Xie 2 , Bin Li 2 , Yujun Bai 2 , Dongxu Zhang 3 , Jing Liang 4 , Chaoni Xiao 2 , Aiguo Zhong 5 , Yanjun Cao 2 , Xiaohui Zheng 2
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Phenylpropanoids comprise a broad spectrum of biologically active natural products. As part of our ongoing research on antiepileptic active compounds from traditional Chinese herb, Acorus calamus var. angustatus Besser, three undescribed phenylpropanoids and twenty-two known ones were isolated. All the undescribed structures were determined by a combination of 1D and 2D NMR, HRMS. In addition, γ-asaronol was identified as racemates and its absolute configuration were determined by the modified Mosher's method and ECD spectral data. Furthermore, some selected isolated compounds were evaluated for their cell viability and neuroprotective activities in H2O2-induced SH-SY5Y cells. α-Asaronol, β-asaronol, 3-(2,4,5-trimethoxyphenyl)propan-1-ol and 1,2,4-trimethoxy-5-(3-methoxypropyl)benzene exerted potential protective activity from neuronal oxidative stress in all test concentrations ranging from 0.01 to 100 μM, in which the neuroprotective activity of β-asaronol was the best.
中文翻译：
来自菖蒲变种的根茎细辛酮衍生的苯丙烷类化合物。安古斯塔斯·贝塞尔
Phenylpropanoids 包括广谱的生物活性天然产物。作为我们正在进行的对来自传统中草药 Acorus calamus var. 的抗癫痫活性化合物研究的一部分。angustatus Besser、三种未描述的苯丙烷和 22 种已知的被分离出来。所有未描述的结构均通过 1D 和 2D NMR、HRMS 的组合确定。此外，γ-细辛醇被鉴定为外消旋物，其绝对构型由改进的 Mosher 方法和 ECD 光谱数据确定。此外，还评估了一些选定的分离化合物在 H2O2 诱导的 SH-SY5Y 细胞中的细胞活力和神经保护活性。α-细辛醇、β-细辛醇、3-(2,4,5-三甲氧基苯基)丙-1-醇和1,2,
更新日期：2020-02-01
中文翻译：
来自菖蒲变种的根茎细辛酮衍生的苯丙烷类化合物。安古斯塔斯·贝塞尔
Phenylpropanoids 包括广谱的生物活性天然产物。作为我们正在进行的对来自传统中草药 Acorus calamus var. 的抗癫痫活性化合物研究的一部分。angustatus Besser、三种未描述的苯丙烷和 22 种已知的被分离出来。所有未描述的结构均通过 1D 和 2D NMR、HRMS 的组合确定。此外，γ-细辛醇被鉴定为外消旋物，其绝对构型由改进的 Mosher 方法和 ECD 光谱数据确定。此外，还评估了一些选定的分离化合物在 H2O2 诱导的 SH-SY5Y 细胞中的细胞活力和神经保护活性。α-细辛醇、β-细辛醇、3-(2,4,5-三甲氧基苯基)丙-1-醇和1,2,
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