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Single dose testosterone administration increases impulsivity in the intertemporal choice task among healthy males.
Hormones and Behavior ( IF 2.5 ) Pub Date : 2019-11-27 , DOI: 10.1016/j.yhbeh.2019.104634
Yin Wu 1 , Bo Shen 2 , Jiajun Liao 1 , Yansong Li 3 , Samuele Zilioli 4 , Hong Li 1
Affiliation  

Circulating levels of testosterone have been positively associated with impulsivity. The present study investigates the effect of testosterone administration on impulsivity in an intertemporal choice task, where participants are given a choice between smaller-sooner rewards and larger-later rewards. Healthy young male participants (n = 111) received a single-dose of 150 mg testosterone gel in a double-blind, placebo-controlled, between-subjects design. At 180 min post-administration, participants performed the decision-making task. Both model-free (i.e., higher indifference point) and model-based (i.e., steeper discounting rate) parameters revealed that testosterone administration increased impulsive choice. This finding supports the hypothesis that exogenous testosterone increases impulsivity among healthy young males in a laboratory task.

中文翻译:

在健康男性中,单剂量睾丸激素的使用会增加他们在跨期选择任务中的冲动性。

睾丸激素的循环水平与冲动呈正相关。本研究调查了在跨期选择任务中给予睾丸激素对冲动的影响,在这种情况下,参与者可以在较小的较早奖赏和较大的较晚奖赏之间进行选择。健康的年轻男性参与者(n = 111)采用双盲,安慰剂对照,受试者间设计接受单剂量150 mg睾丸激素凝胶。给药后180分钟,参与者执行了决策任务。无模型(即较高的无差异点)和基于模型的(即较陡的折现率)参数均表明,睾丸激素给药增加了冲动选择。这一发现支持以下假设:在实验室任务中,外源性睾丸激素会增加健康的年轻男性的冲动性。
更新日期:2019-11-28
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