Computed tomography can provide high-resolution details on nasal anatomy being potentially useful for the assessment of nasal spray deposition. The purpose of this technical note was to present a method based on CT imaging to assess qualitatively and quantitatively the in vitro spray deposition patterns within the sinonasal cavities of a nasal replica obtained by three-dimensional (3D) printing, using iodinated contrast agent labelled solutions with high spatial and temporal resolution. Using a third generation dual-source CT scanner in single energy mode, scans of a nasal replica were acquired following application of iodinated contrast agent labelled aerosols with an iodine concentration of 92.5 mgl/mL. Two software programmes were then utilised (Osirix MD v.9.0, Pixmeo, Geneva, Switzerland; 3mensio, Pie Medical Imaging, Bilthoven, Netherlands) to generate three-dimensional reconstructions of the scans, thus enabling the rapid detection and visualisation of administered single droplets and their voxel-by-voxel localisation. Using this approach, we achieved recovery rates between 84–98% and 89–109% (depending on the software programme) of the total applied aerosol volume.

中文翻译：

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使用3D打印的鼻腔复制品对碘化气雾剂鼻腔沉积物进行体外定性和定量CT评估。

计算机断层扫描可以提供有关鼻部解剖结构的高分辨率细节，这对于评估鼻腔喷雾沉积可能很有用。本技术说明的目的是介绍一种基于CT成像的方法，以定性和定量地评估体外使用高空间和时间分辨率的碘化造影剂标记溶液，通过三维（3D）打印获得的鼻腔复制品的鼻窦腔内形成喷雾沉积模式。在单能模式下使用第三代双源CT扫描仪，在碘浓度为92.5 mgl / mL的碘化造影剂标记的气溶胶后，对鼻腔副本进行扫描。然后使用了两个软件程序（Osirix MD v.9.0，瑞士日内瓦Pixmeo； 3mensio，荷兰比尔托芬的Pie Medical Imaging）生成了三维扫描图，从而能够快速检测并可视化所施用的单个液滴及其逐个体素的本地化。使用这种方法，