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Potential risk of organophosphate exposure in male reproductive system of a non-target insect model Drosophila melanogaster.
Environmental Toxicology and Pharmacology ( IF 3.061 ) Pub Date : 2019-11-27 , DOI: 10.1016/j.etap.2019.103308
Moutushi Mandi,Salma Khatun,Prem Rajak,Abhijit Mazumdar,Sumedha Roy

Based on several adverse reports of pesticides on reproductive efficiency of various organisms, studies on "reproductive toxicity" have gained importance. Fecundity, reflecting reproductive success of any organism, is governed by several factors from female and male reproductive systems. This present study explored morphological and biochemical alterations in the male reproductive system of a non-target model organism, Drosophila melanogaster following chronic sub-lethal exposure (1st instar larvae differentially exposed to 1-6 μg/mL until adulthood) to the organophosphate (OP) pesticide, acephate (chronic LC50 8.71 μg/mL). This study demonstrates altered testis structure, decreased germ cell viability and gross body weight, increased activities of oxidative stress marker lipid peroxidase (LPO), and the endogenous antioxidant enzyme catalase (CAT)in addition with altered expression of reproductive marker proteins like vitellogenin and mitoferrin in acephate-exposed flies when compared to control counterparts. Altered reproductive behavior, indicated by a significant decline in the number of mating pairs, validates the adverse effect of chronic acephate exposure on male reproduction in the non-target insect model D. melanogaster.
更新日期:2019-11-28

 

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