The redundancy of natural product biosynthesis in microbes poses a practical challenge for discovering new antimicrobial compounds from bacteria. The recent application of clustered regularly interspaced short palindromic repeats (CRISPR) technology by Culp et al. to inactivate the production of abundant antibiotics generates a metabolic clean slate for the detection and/or isolation of new and less plentiful antibiotics activated in mutant strains.

中文翻译：

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从废弃的放线菌图书馆中发掘出隐藏的化学潜能。

微生物中天然产物生物合成的冗余提出了从细菌中发现新的抗微生物化合物的实际挑战。Culp等人最近对簇状规则间隔的短回文重复序列（CRISPR）技术的应用。灭活丰富抗生素的生产会产生代谢洁净的状态，以检测和/或分离在突变菌株中激活的新的和含量较低的抗生素。