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Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injury
Cytokine ( IF 3.7 ) Pub Date : 2020-03-01 , DOI: 10.1016/j.cyto.2019.154917 Zhongpeng Hu 1 , Ruiping Du 2 , Lei Xiu 1 , Ziyao Bian 1 , Chaomei Ma 1 , Naoto Sato 3 , Masao Hattori 3 , Haochi Zhang 1 , Yanchen Liang 1 , Shuixing Yu 1 , Xiao Wang 1
Cytokine ( IF 3.7 ) Pub Date : 2020-03-01 , DOI: 10.1016/j.cyto.2019.154917 Zhongpeng Hu 1 , Ruiping Du 2 , Lei Xiu 1 , Ziyao Bian 1 , Chaomei Ma 1 , Naoto Sato 3 , Masao Hattori 3 , Haochi Zhang 1 , Yanchen Liang 1 , Shuixing Yu 1 , Xiao Wang 1
Affiliation
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Ganoderma lucidum is a popular medicinal mushroom, which has been used as therapeutic for centuries in traditional Chinese medicine. Although G. lucidum showed strong protective effects in prevention or treatment of a variety of inflammatory diseases, the mechanisms underlying the anti-inflammatory properties of triterpenes of G. lucidum remain undefined. In the current study, we demonstrated that ethanol extract and triterpenes of G. lucidum specifically suppressed LPS-mediated inflammatory responses. Notably, ganodermanontriol inhibited the expressions and interactions of TLR4 and MyD88, NF-κB translocation to nucleus and its DNA binding activity, phosphorylation of p38, ErK1/2 and JNK. In vivo, we showed that ganodermanontriol effectively prevented LPS/D-Galactosamine-induced liver injury by reducing TNF-α and IL-6 production, and decrease of ALT/AST release. Collectively, our results revealed a novel role in inhibition of inflammatory diseases for triterpenes that may act through potential inhibition of TLR4-MyD88-mediated NF-κB and MAPK signaling pathways.
中文翻译：
灵芝三萜对脂多糖诱导炎症反应及急性肝损伤的保护作用
灵芝是一种广受欢迎的药用蘑菇，几个世纪以来一直被用作中药治疗。尽管灵芝在预防或治疗多种炎症性疾病方面表现出很强的保护作用，但灵芝三萜抗炎特性的潜在机制仍未明确。在目前的研究中，我们证明灵芝的乙醇提取物和三萜特别抑制 LPS 介导的炎症反应。值得注意的是，灵芝三醇抑制 TLR4 和 MyD88 的表达和相互作用、NF-κB 向细胞核的易位及其 DNA 结合活性、p38、ErK1/2 和 JNK 的磷酸化。在体内，我们发现灵芝三醇通过减少 TNF-α 和 IL-6 的产生，有效地预防 LPS/D-半乳糖胺诱导的肝损伤，和 ALT/AST 释放减少。总的来说，我们的结果揭示了三萜在抑制炎症性疾病中的新作用，三萜可能通过潜在抑制 TLR4-MyD88 介导的 NF-κB 和 MAPK 信号通路起作用。
更新日期：2020-03-01
中文翻译：
灵芝三萜对脂多糖诱导炎症反应及急性肝损伤的保护作用
灵芝是一种广受欢迎的药用蘑菇，几个世纪以来一直被用作中药治疗。尽管灵芝在预防或治疗多种炎症性疾病方面表现出很强的保护作用，但灵芝三萜抗炎特性的潜在机制仍未明确。在目前的研究中，我们证明灵芝的乙醇提取物和三萜特别抑制 LPS 介导的炎症反应。值得注意的是，灵芝三醇抑制 TLR4 和 MyD88 的表达和相互作用、NF-κB 向细胞核的易位及其 DNA 结合活性、p38、ErK1/2 和 JNK 的磷酸化。在体内，我们发现灵芝三醇通过减少 TNF-α 和 IL-6 的产生，有效地预防 LPS/D-半乳糖胺诱导的肝损伤，和 ALT/AST 释放减少。总的来说，我们的结果揭示了三萜在抑制炎症性疾病中的新作用，三萜可能通过潜在抑制 TLR4-MyD88 介导的 NF-κB 和 MAPK 信号通路起作用。
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