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Nasal Epithelial Barrier Dysfunction Increases Sensitization and Mast Cell Degranulation in the Absence of Allergic Inflammation
Allergy ( IF 12.6 ) Pub Date : 2019-12-18 , DOI: 10.1111/all.14132 Inge Kortekaas Krohn 1 , Sven F Seys 1, 2 , Gitte Lund 3 , Anne-Charlotte Jonckheere 1 , Isabelle Dierckx de Casterlé 1 , Jan L Ceuppens 1 , Brecht Steelant 1 , Peter W Hellings 4, 5, 6
Allergy ( IF 12.6 ) Pub Date : 2019-12-18 , DOI: 10.1111/all.14132 Inge Kortekaas Krohn 1 , Sven F Seys 1, 2 , Gitte Lund 3 , Anne-Charlotte Jonckheere 1 , Isabelle Dierckx de Casterlé 1 , Jan L Ceuppens 1 , Brecht Steelant 1 , Peter W Hellings 4, 5, 6
Affiliation
Increased epithelial permeability has been reported in allergic rhinitis, with histamine and type‐2 inflammation being responsible for tight junction dysfunction. The impact of an epithelial barrier defect on allergic sensitization and mast cell (MC) degranulation remains speculative.
中文翻译:
在没有过敏性炎症的情况下,鼻上皮屏障功能障碍会增加敏感性和肥大细胞脱颗粒
据报道,过敏性鼻炎上皮通透性增加,组胺和 2 型炎症是导致紧密连接功能障碍的原因。上皮屏障缺陷对过敏性致敏和肥大细胞 (MC) 脱颗粒的影响仍然是推测性的。
更新日期:2019-12-18
中文翻译:
在没有过敏性炎症的情况下,鼻上皮屏障功能障碍会增加敏感性和肥大细胞脱颗粒
据报道,过敏性鼻炎上皮通透性增加,组胺和 2 型炎症是导致紧密连接功能障碍的原因。上皮屏障缺陷对过敏性致敏和肥大细胞 (MC) 脱颗粒的影响仍然是推测性的。