Nasal Epithelial Barrier Dysfunction Increases Sensitization and Mast Cell Degranulation in the Absence of Allergic Inflammation,Allergy

当前位置： X-MOL 学术 › Allergy › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Nasal Epithelial Barrier Dysfunction Increases Sensitization and Mast Cell Degranulation in the Absence of Allergic Inflammation
Allergy ( IF 12.4 ) Pub Date : 2019-12-18 , DOI: 10.1111/all.14132
Inge Kortekaas Krohn ₁ , Sven F Seys _{1,

2} , Gitte Lund ₃ , Anne-Charlotte Jonckheere ₁ , Isabelle Dierckx de Casterlé ₁ , Jan L Ceuppens ₁ , Brecht Steelant ₁ , Peter W Hellings _{4,

5,

6}

Affiliation

Increased epithelial permeability has been reported in allergic rhinitis, with histamine and type‐2 inflammation being responsible for tight junction dysfunction. The impact of an epithelial barrier defect on allergic sensitization and mast cell (MC) degranulation remains speculative.

中文翻译：