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Stabilizing Coacervate by Microfluidic Engulfment Induced by Controlled Interfacial Energy.
Biomacromolecules ( IF 5.5 ) Pub Date : 2019-12-09 , DOI: 10.1021/acs.biomac.9b01579 Kyoung Duck Seo , Sara Shin , Hee Young Yoo , Jiafu Cao 1 , Suyoung Lee , Jin-Wook Yoo 1 , Dong Sung Kim , Dong Soo Hwang
Biomacromolecules ( IF 5.5 ) Pub Date : 2019-12-09 , DOI: 10.1021/acs.biomac.9b01579 Kyoung Duck Seo , Sara Shin , Hee Young Yoo , Jiafu Cao 1 , Suyoung Lee , Jin-Wook Yoo 1 , Dong Sung Kim , Dong Soo Hwang
Affiliation
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Low interfacial energy, an intrinsic property of complex coacervate, enables the complex coacervate to easily encapsulate desired cargo substances, making it widely used in encapsulation applications. Despite this advantage, the low interfacial energy of the complex coacervate makes it unstable against mechanical mixing, and changes in pH and salt concentration. Hence, a chemical cross-linker is usually added to enhance the stability of the complex coacervate at the expense of sacrificing all intrinsic properties of the coacervate, including phase transition of the coacervate from liquid to solid. In this study, we observed an abrupt increase in the interfacial energy of the coacervate phase in mineral oil. By controlling the interfacial energy of the coacervate phase using a microfluidic device, we successfully created double engulfed PEG-diacrylate (PEGDA) coacervate microparticles, named DEPOT, in which the coacervate is engulfed in a cross-linked PEGDA shell. The engulfed coacervate remained as a liquid phase, retained its original low interfacial energy property to encapsulate the desired cargo substances, and infiltrated into the target site by a simple solvent exchange from oil to water.
中文翻译：
通过受控界面能诱导的微流吞噬作用稳定凝聚层。
低界面能是复合凝聚层的固有特性，它使复合凝聚层能够轻松地封装所需的货物，使其广泛用于封装应用中。尽管有这个优点，但是复合凝聚层的低界面能使其对机械混合以及pH和盐浓度的变化不稳定。因此，通常添加化学交联剂以增强复合凝聚层的稳定性，但以牺牲凝聚层的所有固有性质为代价，包括凝聚层从液体到固体的相变。在这项研究中，我们观察到矿物油中凝聚相的界面能突然增加。通过使用微流控设备控制凝聚相的界面能，我们成功地创建了名为DEPOT的双吞噬PEG-二丙烯酸酯（PEGDA）凝聚层微粒，其中凝聚层被包裹在交联的PEGDA壳中。被吞噬的凝聚层保持为液相，保留了其原来的低界面能特性以封装所需的货物，并通过从油到水的简单溶剂交换渗透到目标位置。
更新日期：2019-12-11
中文翻译：
通过受控界面能诱导的微流吞噬作用稳定凝聚层。
低界面能是复合凝聚层的固有特性，它使复合凝聚层能够轻松地封装所需的货物，使其广泛用于封装应用中。尽管有这个优点，但是复合凝聚层的低界面能使其对机械混合以及pH和盐浓度的变化不稳定。因此，通常添加化学交联剂以增强复合凝聚层的稳定性，但以牺牲凝聚层的所有固有性质为代价，包括凝聚层从液体到固体的相变。在这项研究中，我们观察到矿物油中凝聚相的界面能突然增加。通过使用微流控设备控制凝聚相的界面能，我们成功地创建了名为DEPOT的双吞噬PEG-二丙烯酸酯（PEGDA）凝聚层微粒，其中凝聚层被包裹在交联的PEGDA壳中。被吞噬的凝聚层保持为液相，保留了其原来的低界面能特性以封装所需的货物，并通过从油到水的简单溶剂交换渗透到目标位置。
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