Response and place memory systems have long been considered independent, encoding information in parallel, and involving the striatum and hippocampus, respectively. Most experimental studies supporting this view used simple, repetitive tasks, with unrestrained access to spatial cues. They did not give animals an opportunity to correct a response strategy by shifting to a place one, which would demonstrate dynamic, adaptive interactions between both memory systems in the navigation correction process. In a first experiment, rats were trained in the double-H maze for different durations (1, 6, or 14 days; 4 trials/day) to acquire a repetitive task in darkness (forcing a response memory-based strategy) or normal light (placing response and place memory systems in balance), or to acquire a place memory. All rats were given a misleading shifted-start probe trial 24-h post-training to test both their strategy and their ability to correct their navigation directly or in response to negative feedback. Additional analyses focused on the dorsal striatum and the dorsal hippocampus using c-Fos gene expression imaging and, in a second experiment, reversible muscimol inactivation. The results indicate that, depending on training protocol and duration, the striatum, which was unexpectedly the first to come into play in the dual strategy task, and the hippocampus are both required when rats have to correct their navigation after having acquired a repetitive task in a cued environment. Partly contradicting the model established by Packard and McGaugh (1996, Neurobiology of Learning and Memory, vol. 65), these data point to memory systems that interact in more complex ways than considered so far. To some extent, they also challenge the notion of hippocampus-independent response memory and striatum-independent place memory systems.

中文翻译：

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在迷宫导航中响应和放置策略之间的转换：大鼠纹状体或海马体的训练，提示可用性和功能失活的影响。

长期以来，人们一直将响应和位置存储系统视为独立的，并行编码信息并分别涉及纹状体和海马体的系统。支持该观点的大多数实验研究都使用简单，重复的任务，可以不受限制地访问空间线索。他们没有让动物有机会通过转移到某个地方来纠正响应策略，这将证明在导航纠正过程中两个记忆系统之间的动态，自适应交互作用。在第一个实验中，在双H迷宫中训练大鼠不同的持续时间（1、6、14天；每天4次试验），以在黑暗中（强制基于反应记忆的策略）或正常光照下完成重复任务（将响应和位置存储系统保持平衡），或获取位置存储。所有大鼠在训练后的24小时内接受了误导性的移头探针试验，以测试其策略以及直接或响应于负面反馈来纠正其导航的能力。使用c-Fos基因表达成像以及在第二个实验中可逆的麝香酚灭活，其他分析集中在背侧纹状体和背侧海马上。结果表明，根据训练方案和持续时间，当大鼠在完成重复性任务后必须纠正其导航时，纹状体（出人意料地首先在双重策略任务中起作用）和海马都是必需的。提示的环境。与Packard和McGaugh（1996年，《学习与记忆的神经生物学》，第65卷）建立的模型部分矛盾，这些数据指向的存储系统以比迄今为止考虑的更复杂的方式进行交互。在某种程度上，它们还挑战了海马独立反应记忆和纹状体独立位置记忆系统的概念。