Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Wireless, passive strain sensor in a doughnut-shaped contact lens for continuous non-invasive self-monitoring of intraocular pressure.
Lab on a Chip ( IF 6.1 ) Pub Date : 2019-11-26 , DOI: 10.1039/c9lc00735k M Hossein M Kouhani 1 , Jiajia Wu 1 , Arman Tavakoli 2 , Arthur J Weber 3 , Wen Li 1
Lab on a Chip ( IF 6.1 ) Pub Date : 2019-11-26 , DOI: 10.1039/c9lc00735k M Hossein M Kouhani 1 , Jiajia Wu 1 , Arman Tavakoli 2 , Arthur J Weber 3 , Wen Li 1
Affiliation
|
After cataract, glaucoma is the second leading cause of blindness worldwide and real-time monitoring of intraocular pressure (IOP) is of great demand. We present a wireless, passive sensor sitting inside a customized, planar and circular doughnut-shaped contact lens capable of continuous monitoring of the change in the curvature of cornea caused by IOP fluctuations. The sensor consists of a constant capacitor and a variable inductor in the form of a stretchable, closed-loop, serpentine wire that serves as both the sensor and the antenna. Results show a pressure responsivity of 523 kHz per 1% axial strain on a pressurized polydimethylsiloxane membrane and 35.1 kHz per 1 mmHg change in the IOP of a canine eye. The sensor is tested for stability and shows unvaried characteristics after repeated cycles and parasitic movements. Predictable influences of temperature and humidity on the sensor response are also verified experimentally, which can be canceled out using real-time calibration with temperature and humidity sensors to integrate with a reader device. The design reported here has numerous advantages, such as design simplicity, component reliability, high responsivity, and low cost, thereby opening up potential opportunities for the translation of this non-invasive, continuous IOP monitoring technique into clinical applications.
中文翻译：
环形接触镜中的无线被动应变传感器，用于连续无创地自我监测眼内压。
青光眼仅次于白内障，是世界范围内失明的第二大原因，对眼内压（IOP）的实时监测具有巨大的需求。我们介绍了一种无线的无源传感器，它位于定制的平面和圆形甜甜圈形隐形眼镜内，能够连续监测由IOP波动引起的角膜曲率变化。传感器由恒定电容和可变电感器组成，该可变电感器为可伸展的闭环蛇形导线形式，既充当传感器又充当天线。结果表明，加压聚二甲基硅氧烷膜上的轴向响应（每1％轴向应变）为523 kHz，每1 mmHg眼压的变化为35.1 kHz。该传感器经过了稳定性测试，并在重复循环和寄生运动后显示出不变的特性。温度和湿度对传感器响应的可预测影响也已通过实验验证，可以通过使用温度和湿度传感器与读取器设备集成的实时校准来消除。本文报道的设计具有许多优点，例如设计简单，组件可靠性，高响应性和低成本，从而为将该非侵入性，连续IOP监测技术转化为临床应用打开了潜在的机会。
更新日期：2019-11-26
中文翻译：
环形接触镜中的无线被动应变传感器，用于连续无创地自我监测眼内压。
青光眼仅次于白内障，是世界范围内失明的第二大原因，对眼内压（IOP）的实时监测具有巨大的需求。我们介绍了一种无线的无源传感器，它位于定制的平面和圆形甜甜圈形隐形眼镜内，能够连续监测由IOP波动引起的角膜曲率变化。传感器由恒定电容和可变电感器组成，该可变电感器为可伸展的闭环蛇形导线形式，既充当传感器又充当天线。结果表明，加压聚二甲基硅氧烷膜上的轴向响应（每1％轴向应变）为523 kHz，每1 mmHg眼压的变化为35.1 kHz。该传感器经过了稳定性测试，并在重复循环和寄生运动后显示出不变的特性。温度和湿度对传感器响应的可预测影响也已通过实验验证，可以通过使用温度和湿度传感器与读取器设备集成的实时校准来消除。本文报道的设计具有许多优点，例如设计简单，组件可靠性，高响应性和低成本，从而为将该非侵入性，连续IOP监测技术转化为临床应用打开了潜在的机会。
京公网安备 11010802027423号