Background Many therapeutic options are available to glaucoma patients. One recent therapeutic option is minimally invasive glaucoma surgical (MIGS) devices. It is unclear how patients view different treatments and which patient-reported outcomes would be most relevant in patients with mild to moderate glaucoma. We developed a questionnaire for patients eligible for MIGS devices and a patient preference study to examine the value patients place on certain outcomes associated with glaucoma and its therapies. Objectives To summarize the progress to date. Methods Questionnaire development: We drafted the questionnaire items based on input from one physician and four patient focus groups, and a review of the literature. We tested item clarity with six cognitive interviews. These items were further refined. Patient preference study: We identified important benefit and risk outcomes qualitatively using semi-structured, one-on-one interviews with patients who were eligible for MIGS devices. We then prioritized these outcomes quantitatively using best-worst scaling methods. Results Questionnaire testing : Three concepts were deemed relevant for the questionnaire: functional limitations, symptoms, and psychosocial factors. We will evaluate the reliability and validity of the 52-item draft questionnaire in an upcoming field test. Patient preference study: We identified 13 outcomes that participants perceived as important. Outcomes with the largest relative importance weights were “adequate IOP control” and “drive a car during the day.” Conclusions Patients have the potential to steer clinical research towards outcomes that are important to them. Incorporating patients’ perspectives into the MIGS device development and evaluation process may expedite innovation and availability of these devices.

中文翻译：

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患者报告的结果测量和患者对微创青光眼手术设备的偏好


背景 青光眼患者有许多治疗选择。最近的一种治疗选择是微创青光眼手术 (MIGS) 设备。目前尚不清楚患者如何看待不同的治疗方法，以及哪些患者报告的结果与轻度至中度青光眼患者最相关。我们为符合 MIGS 设备资格的患者制定了一份调查问卷，并开展了一项患者偏好研究，以检查患者对青光眼及其治疗相关某些结果的重视程度。目标 总结迄今为止的进展。方法 调查问卷的制定：我们根据一名医生和四个患者焦点小组的意见以及文献综述起草了调查问卷项目。我们通过六次认知访谈测试了项目清晰度。这些项目被进一步细化。患者偏好研究：我们通过对符合 MIGS 设备资格的患者进行半结构化、一对一的访谈，定性地确定了重要的获益和风险结果。然后，我们使用最佳-最差缩放方法对这些结果进行定量优先级排序。结果问卷测试：三个概念被认为与问卷相关：功能限制、症状和社会心理因素。我们将在即将进行的现场测试中评估 52 项草稿问卷的信度和效度。患者偏好研究：我们确定了参与者认为重要的 13 项结果。相对重要性权重最大的结果是“适当的眼压控制”和“白天开车”。结论 患者有潜力引导临床研究取得对他们重要的结果。 将患者的观点纳入 MIGS 设备开发和评估过程可能会加快这些设备的创新和可用性。