This preliminary study aims to prepare porous extractant-incorporated membranes (EIMs) containing base polymer cellulose triacetate (CTA), tri-n-octylphosphine oxide (TOPO), and trioctylammonium chloride (Aliquat 336) prepared by non-solvent induced phase inversion for selective removal of p-cresol from simulated serum. The surface morphology and pore structure of the EIMs were investigated using a field emission scanning electron microscope (FE-SEM) and nitrogen sorptiometer, respectively. The functional groups and chemical composition of the EIMs were characterized by the Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and X-ray photoelectron spectrometry (XPS), respectively. The interactions between uremic toxins (p-cresol, creatinine, and urea) and TOPO or Aliquat 336, studied independently by liquid-liquid extraction, were ascribed to hydrogen bonding. Batch tests showed that the addition of TOPO strongly favored p-cresol adsorption; for example, an adsorption capacity of 2.08 mmol/g of the EIM composed of 54.5 wt% CTA, 27.3 wt% Aliquat 336, and 18.2 wt% TOPO was obtained at 37°C, compared to a negligibly small capacity for creatinine and urea. Cross-flow dynamic experiments revealed that the maximum adsorption of p-cresol in a multi-component serum was 0.75 mmol/g of the EIM under the conditions studied. The high adsorption selectivity for p-cresol may make the prepared EIMs promising and potential for efficient removal of p-cresol from simulated serum.

这一初步研究的目的是制备包含基础聚合物的三乙酸纤维素（CTA），三多孔萃取剂的结合膜（EIMS）ñ由非溶剂引起的相转化用于选择性制备-octylphosphine氧化膦（TOPO），三辛基铵和氯化（的Aliquat 336）从模拟血清中去除对甲酚。分别使用场发射扫描电子显微镜（FE-SEM）和氮气吸能计研究了EIM的表面形态和孔结构。EIM的官能团和化学组成分别通过傅立叶变换红外光谱衰减全反射（FTIR-ATR）和X射线光电子能谱（XPS）进行表征。尿毒症毒素之间的相互作用（p-甲酚，肌酐和尿素）和TOPO或Aliquat 336（通过液-液萃取进行了独立研究）归因于氢键。批处理试验表明，加入TOPO强烈促进了对甲酚的吸附。例如，在37℃时，由54.5 wt％的CTA，27.3 wt％的Aliquat 336和18.2 wt％的TOPO组成的EIM的吸附容量为2.08 mmol / g相比之下，肌酐和尿素的容量可忽略不计。错流动力学实验表明，在所研究的条件下，多组分血清中对甲酚的最大吸附量为0.75 mmol / g EIM。对对甲酚的高吸附选择性可能使所制备的EIM具有前景，并有望从模拟血清中有效去除对甲酚。