A-kinase anchoring proteins (AKAPs) play crucial roles in regulating compartmentalized multi-protein signaling networks related to PKA-mediated phosphorylation. The mitochondrial AKAP - AKAP1 proteins are enriched in heart and play cardiac protective roles. This review aims to thoroughly summarize AKAP1 variants from their sequence features to the structure-function relationships between AKAP1 and its binding partners, as well as the molecular mechanisms of AKAP1 in cardiac hypertrophy, hypoxia-induced myocardial infarction and endothelial cells dysfunction, suggesting AKAP1 as a candidate for cardiovascular therapy.

中文翻译：

---

A激酶锚定蛋白1（AKAP1）及其在某些心血管疾病中的作用。

A激酶锚定蛋白（AKAP）在调节与PKA介导的磷酸化有关的间隔化多蛋白信号网络中起关键作用。线粒体AKAP-AKAP1蛋白在心脏中富集并发挥心脏保护作用。这篇综述旨在从序列特征到AKAP1及其结合伙伴之间的结构-功能关系，以及AKAP1在心肌肥大，低氧诱导的心肌梗塞和内皮细胞功能障碍中的分子机制，从其序列特征彻底总结，心血管疗法的候选人。