During development, tissues are submitted to high variation of compression and tension forces. The roles of the cell wall, the cytoskeleton, the turgor pressure and the cell geometry during this process have received due attention. In contrast, apart from its role in the establishment of turgor pressure, the involvement of the plasma membrane as a transducer of mechanical forces during development has been under studied. Force-gated (FG) or Mechanosensitive (MS) ion channels embedded in the bilayer represent 'per se' archetypal mechanosensor able to directly and instantaneously transduce membrane forces into electrical and calcium signals. We discuss here how their fine-tuning, combined with their ability to detect micro-curvature and local membrane tension, allows FG channels to transduce mechanical cues into developmental signals.

中文翻译：

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钙和质膜强迫门控离子通道的发展。

在发育过程中，组织承受着很大的压力和张力变化。在此过程中，细胞壁，细胞骨架，膨胀压力和细胞几何结构的作用已受到应有的重视。相反，除了其在建立膨胀压力中的作用外，还研究了质膜在发育过程中作为机械力的转换器的参与。嵌入双层中的强制门控（FG）或机械敏感（MS）离子通道代表“本身”的原型机械传感器，能够将膜力直接和即时地转换为电信号和钙信号。我们在这里讨论它们的微调，结合其检测微曲率和局部膜张力的能力，如何使FG通道将机械信号转化为发育信号。