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A Dose Metrics Perspective on the Association of Gold Nanomaterials with Algal Cells
Environmental Science & Technology Letters ( IF 8.9 ) Pub Date : 2019-11-26 , DOI: 10.1021/acs.estlett.9b00683
Fazel Abdolahpur Monikh 1 , Benjamin Fryer 2 , Daniel Arenas-Lago 1 , Martina G. Vijver 1 , Gopala Krishna Darbha 3 , Eugenia Valsami-Jones 2 , Willie J. G. M. Peijnenburg 1, 4
Affiliation  

A single-cell inductively coupled plasma mass spectrometry technique was used to explore the influence of particle properties on the association of nanomaterials (NMs) with algal cells. We investigated the effect of particle size, shape, and surface chemistry [citrate and natural organic matter (NOM) coating] on the association of gold (Au) NMs with algal cells using particle mass, particle number, surface area (SA), and volume-specific surface area (VSSA) as dose metrics. Particle number was found to be a better dose metric than particle mass, SA, and VSSA in view of the strong correlation obtained between the number of associated Au NMs with cells and the number of Au NMs in the exposure medium. When particle number was used as the dose metric, there was no selectivity of Au NM cellular association irrespective of particle size and shape, and the cellular association was proportional to the effective number of particles to which the cells were exposed. The surface chemistry of the Au NMs, however, decreased the level of cellular association of some NMs (60 nm spheres). Particle number is the main element used for the classification of NMs according to the recommended definition for NM by the European Commission. The key finding of our study supports the implementation of this definition for safety purposes.

中文翻译:

金纳米材料与藻类细胞缔合的剂量计量视角。

使用单细胞感应耦合等离子体质谱技术来研究颗粒性质对纳米材料(NMs)与藻类细胞缔合的影响。我们使用颗粒质量,颗粒数量,表面积(SA)和颗粒尺寸,研究了颗粒大小,形状和表面化学性质[柠檬酸盐和天然有机物(NOM)涂层]对金(Au)NMs与藻类细胞的缔合的影响。体积比表面积(VSSA)作为剂量指标。鉴于与细胞相关的Au NMs数量与曝光介质中的Au NMs数量之间具有很强的相关性,因此发现颗粒数比颗粒质量,SA和VSSA更好。当使用颗粒数作为剂量度量标准时,无论颗粒大小和形状如何,Au NM细胞缔合都没有选择性,并且细胞缔合与细胞暴露于其中的有效颗粒数成正比。然而,Au NMs的表面化学性质降低了某些NMs(60 nm球形)的细胞缔合水平。根据欧洲委员会对NM的推荐定义,颗粒数是用于NM分类的主要元素。我们研究的主要发现支持出于安全目的执行此定义。
更新日期:2019-11-28
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