Development of Near-Infrared Fluorescent Probes for Use in Alzheimer's Disease Diagnosis.,Bioconjugate Chemistry

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Development of Near-Infrared Fluorescent Probes for Use in Alzheimer's Disease Diagnosis.
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2019-12-16 , DOI: 10.1021/acs.bioconjchem.9b00695
Jian Yang ₁ , Fantian Zeng ₁ , Yiran Ge ₁ , Kewen Peng ₁ , Xiaofang Li ₁ , Yuyan Li ₂ , Yungen Xu _{1,

2}

Affiliation

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder. Currently, there are no available treatments that can effectively stop or reverse the progression of the disease, and existing therapeutics can only alleviate the symptoms. Thus, it remains urgent to develop effective early-stage AD diagnostic methods. In recent years, the search for near-infrared fluorescent (NIRF) probes of AD hallmarks has become a promising research field. In this Review, we will focus on small-molecule NIRF probes used to detect β-amyloid, tau proteins, and reactive oxygen species in vivo during the past 4 years. We believe that some new directions we raise herein will benefit the future development of NIRF probes in the field of AD research.

中文翻译：

用于阿尔茨海默氏病诊断的近红外荧光探针的开发。

阿尔茨海默氏病（AD）是一种不可逆的神经退行性疾病。当前，没有可用的疗法可以有效地阻止或逆转疾病的进展，并且现有的疗法只能缓解症状。因此，迫切需要开发有效的早期AD诊断方法。近年来，寻找具有AD标志的近红外荧光（NIRF）探针已成为有前途的研究领域。在本综述中，我们将重点介绍过去4年中用于体内检测β-淀粉样蛋白，tau蛋白和活性氧的小分子NIRF探针。我们相信，本文提出的一些新方向将有益于AD研究领域中NIRF探针的未来发展。

更新日期：2019-12-17

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