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Establishing reference intervals of coagulation indices based on the ACL Top 700 system for children in Southwestern Fujian, China.
Clinical Biochemistry ( IF 2.5 ) Pub Date : 2019-11-23 , DOI: 10.1016/j.clinbiochem.2019.11.005 Huifen Zhang 1 , Jiming Li 2 , Haichen Chen 3 , Xingdong Wu 1
Clinical Biochemistry ( IF 2.5 ) Pub Date : 2019-11-23 , DOI: 10.1016/j.clinbiochem.2019.11.005 Huifen Zhang 1 , Jiming Li 2 , Haichen Chen 3 , Xingdong Wu 1
Affiliation
BACKGROUND
Till date, China has not issued industry standards for reference intervals (RIs) of pediatric blood coagulation indices. Here, we evaluated changes in the coagulation indices in the venous blood of healthy children aged 29 days to 12 years derived using the ACL Top 700 system and established appropriate RIs.
METHODS
We analyzed venous blood from 1770 healthy children for five coagulation indices. RIs were established according to the Clinical and Laboratory Standards Institute C28-A3c guideline.
RESULTS
The coagulation indices were grouped by age. For prothrombin time (PT) and international normalization ratio (INR), the RIs of infants and toddlers were identical; preschool children had the same RI as school-age children. Pediatric RIs for PT and INR were slightly lower than those for adults. The RIs of activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (FIB) in childhood were divided into two groups by age (1 month to 1 year and 1-12 years). The RI of APTT in infants was the widest; the overall level of FIB in infants was the lowest; children's APTT and FIB RIs were lower than those of adults. The pattern of TT values and RI trends in childhood were similar to those of APTT.
CONCLUSIONS
There were minor changes in the RIs of coagulation indices for children. The RIs of PT, INR, APTT, TT, and FIB must be grouped by age. The RIs of coagulation indices for children were different from those for adults; therefore, establishing separate RIs for children is necessary.
更新日期：2019-11-26
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