Non-genetic inheritance of metabolic state over multiple generations has been widely reported in insects. The present study uses the fruit fly, Drosophila melanogaster, to assess whether lifespan, physiological traits and metabolism are affected by the dietary protein-to-carbohydrate ratio (P:C) of the prior adult generation. Groups of parental flies were fed diets with different P:C ratios. Their progeny groups were raised on the same diet so the only variable in the experiments was the diet fed to the parents. Parental P:C affected the lifespan of female offspring, however had no impact on F1 males survival. Low parental P:C increased feeding rate in progeny. An increase in the P:C ratio from 0.03 to 0.65 decreased the levels of body glucose and trehalose in the offspring and a similar tendency was observed in the levels of circulating hemolymph glucose and trehalose. Offspring also accumulated less triglycerides but more glycogen when parents were fed a low P:C diet. Our study indicates that the parental dietary P:C ration has a strong impact on the lifespan, reproduction, appetite and metabolism in the offspring generation.

中文翻译：

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父母的饮食中蛋白质与碳水化合物的比例会影响果蝇的后代寿命和新陈代谢。

昆虫已广泛报道了多代代谢状态的非遗传遗传。本研究使用果蝇果蝇（Drosophila melanogaster）来评估寿命，生理特征和新陈代谢是否受到前成年一代饮食中蛋白质与碳水化合物的比例（P：C）的影响。以不同的P：C比例喂食父母亲果蝇。他们的后代组以相同的饮食饲养，因此实验中唯一的变量是喂养父母的饮食。父母亲P：C影响了雌性后代的寿命，但是对F1雄性的存活率没有影响。较低的父母亲P：C增加了子代的饲喂率。P：C比率从0.03增加到0。65降低了后代的体内葡萄糖和海藻糖水平，循环血淋巴葡萄糖和海藻糖水平也观察到了类似的趋势。当父母给父母喂低P：C的饮食时，后代的甘油三酸酯也较少，但糖原却更多。我们的研究表明，父母饮食中的P：C比例对后代的寿命，繁殖，食欲和代谢有很大影响。