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Coumarins and acridone alkaloids with α-glucosidase inhibitory and antioxidant activity from the roots of Paramignya trimera
Phytochemistry Letters ( IF 1.3 ) Pub Date : 2019-11-22 , DOI: 10.1016/j.phytol.2019.10.010
Duong H. Trinh , Phuong T. Tran , Binh T.D. Trinh , Hieu T. Nguyen , Hiep D. Nguyen , Ly D. Ha , Lien-Hoa D. Nguyen

Three new compounds comprising two coumarins, paramicoumarins A (1) and B (2), and an acridone alkaloid, paramiacridone (3), together with seven known compounds, were isolated from the n-hexane extract of the roots of Paramignya trimera (Rutaceae). Their structures were elucidated using spectroscopic methods, mainly 1D and 2D NMR. α-Glucosidase inhibition and DPPH radical scavenging activity of the compounds and fifteen other compounds previously isolated from the roots of this plant were evaluated. Most of the compounds exhibited stronger α-glucosidase inhibitory activity than acarbose, the positive control (IC50 = 223.0 μM), and the new compounds paramiacridone (3) and paramicoumarin B (2) showed good inhibitory effect (IC50 = 62.5 and 65.5 μM, respectively). In the DPPH test for radical scavenging activity, the acridone alkaloid glycocitrin III (17) exhibited the highest antioxidant activity (IC50 = 84.2 μM) (compared with the positive control, ascorbic acid, IC50 = 152.7 μM).



中文翻译:

香附草根中具有α-葡糖苷酶抑制作用和抗氧化活性的香豆素和cri啶酮生物碱

包括两个香豆素三个新的化合物,paramicoumarins A(1)和B(2),和吖啶酮生物碱,paramiacridone(3),加上7种已知化合物中,从分离Ñ的根部的己烷提取物Paramignya三聚体(芸香科)。使用主要是1D和2D NMR的光谱方法阐明了它们的结构。评价了该化合物和先前从该植物的根中分离的其他十五种化合物的α-葡萄糖苷酶抑制作用和DPPH自由基清除活性。大多数化合物显示出 比阿卡波糖,阳性对照(IC 50 = 223.0μM)和新化合物对mi啶酮(3)更强的α-葡萄糖苷酶抑制活性(3)和拟除虫菊酯B(2)表现出良好的抑制作用(IC 50分别 为62.5和65.5μM )。在DPPH自由基清除活性测试中,cri啶酮生物碱糖苷III(17)表现出最高的抗氧化活性(IC 50  = 84.2μM)(与阳性对照抗坏血酸相比,IC 50  = 152.7μM)。

更新日期:2019-11-22
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