Mitochondrial dysfunction is involved in the pathology of two major blinding retinal diseases, diabetic retinopathy (DR) and age-related macular degeneration (AMD). These diseases accumulate mitochondrial defects in distinct retinal subcellular structures, the vascular/neural network in DR and the retinal pigment epithelium (RPE) in AMD. These mitochondrial defects cause a metabolic crisis that drives disease. With no treatments to stop these diseases, coupled with an increasing population suffering from AMD and DR, there is an urgent need to develop new therapeutics targeting the mitochondria to prevent or reverse disease-specific pathology.

中文翻译：

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线粒体缺陷导致退行性视网膜疾病。


线粒体功能障碍涉及两种主要致盲性视网膜疾病：糖尿病性视网膜病变（DR）和年龄相关性黄斑变性（AMD）的病理学。这些疾病在不同的视网膜亚细胞结构、DR 中的血管/神经网络和 AMD 中的视网膜色素上皮 (RPE) 中积累线粒体缺陷。这些线粒体缺陷会导致代谢危机，从而引发疾病。由于没有治疗方法可以阻止这些疾病，加上患有 AMD 和 DR 的人口不断增加，迫切需要开发针对线粒体的新疗法来预防或逆转疾病特异性病理。