The IL-12-STAT4 axis in the pathogenesis of human systemic lupus erythematosus.,European Journal of Immunology

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The IL-12-STAT4 axis in the pathogenesis of human systemic lupus erythematosus.
European Journal of Immunology ( IF 4.5 ) Pub Date : 2019-12-03 , DOI: 10.1002/eji.201948134
Hideki Ueno _{1,

2,

3,

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Affiliation

Generation of autoantibodies is a hallmark of systemic lupus erythematosus (SLE). As demonstrated in a number of lupus mouse models, recent evidence suggests that both GC and extrafollicular pathways contribute to the generation of autoantibodies also in human SLE, and that CD11c+ IgD- CD27- (double negative:DN) B cells play a central role in the latter pathway. In this mini-review, the author will first briefly summarize the features of CD11c+ DN B cells in human SLE, and discuss how the IL-12-STAT4 axis might contribute to the generation of autoantibodies in SLE. In addition, various types of CD4+ helper T cell subsets promoting the generation of autoantibodies in SLE will be described, and finally it will be discussed how these recent discoveries contribute to understanding of SLE pathogenesis and treatment of SLE patients.

中文翻译：

IL-12-STAT4轴在人类系统性红斑狼疮的发病机理中。

自身抗体的产生是系统性红斑狼疮（SLE）的标志。正如在许多狼疮小鼠模型中所证明的那样，最近的证据表明，GC和卵泡外途径都有助于人类SLE中自身抗体的产生，并且CD11c + IgD- CD27-（双阴性：DN）B细胞在人SLE中起着核心作用。后一种途径。在本微型综述中，作者将首先简要概述人类SLE中CD11c + DN B细胞的特征，并讨论IL-12-STAT4轴如何可能有助于SLE中自身抗体的产生。此外，将描述促进SLE中自身抗体生成的各种类型的CD4 +辅助性T细胞亚群，最后将讨论这些最新发现如何有助于理解SLE发病机理和治疗SLE患者。

更新日期：2019-12-03

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