A subset of patients with early gastric cancer demonstrate early recurrence and poor survival despite margin-negative resection. This study used an extremes-of-survivorship approach to identify an association between TP53 hotspot mutations co-occurring with loss of heterozygosity and unexpectedly poor survival in early gastric cancer. This distinct genomic profile may be a novel biomarker of poor survival in patients with completely resected early gastric cancer, and warrants large-scale validation. Promising, validation needed.

中文翻译：

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早期胃癌切除后存活率低：存活率分析的极端性揭示了独特的基因组特征。

尽管切缘阴性，但一部分早期胃癌患者表现出早期复发且生存率较差。这项研究使用了一种极端的生存方法，来确定与杂合性丧失共同发生的TP53热点突变与早期胃癌的出乎意料的不良生存之间的关联。这种独特的基因组概况可能是完全切除的早期胃癌患者生存不良的新型生物标志物，值得大规模验证。有前途的，需要验证。