Most recommended medical interventions reach P < 0.005 for their primary outcomes in meta-analyses.,International Journal of Epidemiology

当前位置： X-MOL 学术 › Int. J. Epidemiol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Most recommended medical interventions reach P < 0.005 for their primary outcomes in meta-analyses.
International Journal of Epidemiology ( IF 6.4 ) Pub Date : 2019-11-25 , DOI: 10.1093/ije/dyz241
Despina Koletsi _{1,

2} , Marco Solmi _{3,

4} , Nikolaos Pandis ₅ , Padhraig S Fleming ₆ , Christoph U Correll _{7,

8,

9,

10} , John P A Ioannidis _{11,

12,

13,

14,

15}

Affiliation

Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
Clinic of Orthodontics and Pediatric Dentistry, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
Department of Neuroscience, University of Padua, Padua, Italy.
Padua Neuroscience Center, University of Padua, Padua, Italy.
Department of Orthodontics and Dentofacial Orthopedics, School of Dental Medicine, Medical Faculty, University of Bern, Bern, Switzerland.
Department of Oral Bioengineering, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Department of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA.
Department of Psychiatry and Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
The Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, NY, USA.
Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany.
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA.
Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA.
Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, CA, USA.
Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, CA, USA.

It has been proposed that the threshold of statistical significance should shift from P-value < 0.05 to P-value < 0.005, but there is concern that this move may dismiss effective, useful interventions. We aimed to assess how often medical interventions are recommended although their evidence in meta-analyses of randomized trials lies between P-value = 0.05 and P-value = 0.005.

中文翻译：

对于荟萃分析的主要结局，大多数推荐的医学干预措施达到P <0.005。

已经提出统计显着性的阈值应从P值<0.05转变为P值<0.005，但是人们担心此举可能会取消有效的，有用的干预措施。我们旨在评估推荐进行医疗干预的频率，尽管在随机试验的荟萃分析中，医疗干预的证据介于P值= 0.05和P值= 0.005之间。

更新日期：2019-11-25

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11