Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets.,Nature Microbiology

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Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets.
Nature Microbiology ( IF 20.5 ) Pub Date : 2019-11-25 , DOI: 10.1038/s41564-019-0609-0
Masaki Imai ₁ , Makoto Yamashita ₁ , Yuko Sakai-Tagawa ₁ , Kiyoko Iwatsuki-Horimoto ₁ , Maki Kiso ₁ , Jurika Murakami ₁ , Atsuhiro Yasuhara ₁ , Kosuke Takada ₁ , Mutsumi Ito ₁ , Noriko Nakajima ₂ , Kenta Takahashi ₂ , Tiago J S Lopes _{1,

3} , Jayeeta Dutta ₄ , Zenab Khan ₄ , Divya Kriti ₄ , Harm van Bakel ₄ , Akifumi Tokita _{5,

6} , Haruhisa Hagiwara _{6,

7} , Naomi Izumida _{6,

8} , Haruo Kuroki ₉ , Tamon Nishino _{6,

10} , Noriyuki Wada _{6,

11} , Michiko Koga ₁₂ , Eisuke Adachi ₁₃ , Daisuke Jubishi _{1,

14} , Hideki Hasegawa _{2,

15} , Yoshihiro Kawaoka _{1,

3,

16}

Affiliation

Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Clinic Bambini, Tokyo, Japan.
Members of the Tokyo Pediatric Association Public Health Committee, Tokyo, Japan.
Hagiwara Clinic, Tokyo, Japan.
Akebonocho Clinic, Tokyo, Japan.
Sotobo Children's Clinic, Chiba, Japan.
Alpaca Kids Ent Clinic, Tokyo, Japan.
Wada Pediatric Clinic, Tokyo, Japan.
Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of the Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Nezu Clinic, Tokyo, Japan.
Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan.

Here we report the isolation of the influenza A/H1N1 2009 pandemic (A/H1N1pdm) and A/H3N2 viruses carrying an I38T mutation in the polymerase acidic protein-a mutation that confers reduced susceptibility to baloxavir marboxil-from patients before and after treatment with baloxavir marboxil in Japan. These variants showed replicative abilities and pathogenicity that is similar to those of wild-type isolates in hamsters; they also transmitted efficiently between ferrets by respiratory droplets.

中文翻译：

从日本患者中分离出的对巴洛沙韦敏感性降低的甲型流感病毒变异体适合并通过呼吸道飞沫传播。

在此，我们报告了从 2009 年甲型 H1N1 流感大流行 (A/H1N1pdm) 和 A/H3N2 病毒中分离出聚合酶酸性蛋白中携带 I38T 突变的病毒，该突变会降低对巴洛沙韦马波西的敏感性巴洛沙韦 Marboxil 在日本。这些变异体在仓鼠中表现出与野生型分离株相似的复制能力和致病性；它们还通过呼吸道飞沫在雪貂之间有效传播。

更新日期：2019-11-26

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