Night shift work, behavioral rhythms, and the common MTNR1B risk single nucleotide polymorphism (SNP), rs10830963, associate with type 2 diabetes; however, whether they exert joint effects to exacerbate type 2 diabetes risk is unknown. Among employed participants of European ancestry in the UK Biobank (N = 189,488), we aimed to test the cross-sectional independent associations and joint interaction effects of these risk factors on odds of type 2 diabetes (n = 5,042 cases) and HbA1c levels (n = 175,156). Current shift work, definite morning or evening preference, and MTNR1B rs10830963 risk allele associated with type 2 diabetes and HbA1c levels. The effect of rs10830963 was not modified by shift work schedules. While marginal evidence of interaction between self-reported morningness-eveningness preference and rs10830963 on risk of type 2 diabetes was seen, this interaction did not persist when analysis was expanded to include all participants regardless of employment status and when accelerometer-derived sleep midpoint was used as an objective measure of morningness-eveningness preference. Our findings suggest that MTNR1B risk allele carriers who carry out shift work or have more extreme morningness-eveningness preference may not have enhanced risk of type 2 diabetes.

中文翻译：

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英国生物库通过轮班工作和早晚偏好评估 MTNR1B 2 型糖尿病遗传风险修饰

夜班工作、行为节律和常见的 MTNR1B 风险单核苷酸多态性 (SNP)，rs10830963，与 2 型糖尿病相关；然而，它们是否发挥联合作用以加剧 2 型糖尿病风险尚不清楚。在英国生物库 (N = 189,488) 的欧洲血统的受雇参与者中，我们旨在测试这些风险因素对 2 型糖尿病 (n = 5,042 例) 和 HbA1c 水平的横断面独立关联和联合交互作用。 n = 175,156)。当前轮班工作、明确的早晚偏好以及与 2 型糖尿病和 HbA1c 水平相关的 MTNR1B rs10830963 风险等位基因。rs10830963 的效果不受轮班工作时间表的影响。虽然看到了自我报告的早晚偏好与 rs10830963 对 2 型糖尿病风险之间相互作用的边际证据，但当分析扩展到包括所有参与者（无论就业状况如何）以及使用加速度计衍生的睡眠中点时，这种相互作用并没有持续存在作为早晚偏好的客观衡量标准。我们的研究结果表明，MTNR1B 风险等位基因携带者进行轮班工作或具有更极端的早晚偏好可能不会增加 2 型糖尿病的风险。