OBJECTIVE The N2 ERP component is used as a biomeasure of executive function in children with autism spectrum disorder (ASD). The aim of the current study was to evaluate the test-retest reliability of N2 amplitude in this population. METHODS ERPs were recorded from 7 to 11-year-old children with ASD during Flanker (n = 21) and Go/Nogo tasks (n = 14) administered at two time points separated by approximately three months. Reliability of the N2 component was examined using intraclass correlation coefficients (ICCs). RESULTS Reliability for mean N2 amplitude obtained during the Flanker task was moderate (congruent: ICC = 0.542, 95% CI [0.173, 0.782]; incongruent: ICC = 0.629, 95% CI [0.276, 0.831]). Similarly, reliability for the Go/Nogo task ranged from moderate to good ('go': ICC = 0.817, 95% CI [0.535, 0.937]; 'nogo': ICC = 0.578, 95% CI [0.075, 0.843]). CONCLUSIONS These findings support the use of N2 amplitude as a biomeasure of executive function in school-aged children with ASD. SIGNIFICANCE This research addresses a critical gap in clinical neurophysiology, as an understanding of the stability and reliability of the N2 component is needed in order to differentiate variance explained by repeated measurement versus targeted treatments and interventions.

中文翻译：

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自闭症谱系障碍 (ASD) 学龄儿童 N2 事件相关电位的重测信度

目标 N2 ERP 组件被用作自闭症谱系障碍 (ASD) 儿童执行功能的生物测量。本研究的目的是评估该人群中 N2 振幅的重测信度。方法 记录 7 至 11 岁 ASD 儿童在 Flanker（n = 21）和 Go/Nogo 任务（n = 14）期间在相隔约三个月的两个时间点执行的 ERP。使用组内相关系数 (ICC) 检查 N2 组件的可靠性。结果 在 Flanker 任务期间获得的平均 N2 振幅的可靠性中等（一致：ICC = 0.542，95% CI [0.173, 0.782]；不一致：ICC = 0.629, 95% CI [0.276, 0.831]）。同样，Go/Nogo 任务的可靠性从中等到良好（“go”：ICC = 0.817，95% CI [0.535，0.937]；“nogo”：ICC = 0.578，95% 置信区间 [0.075, 0.843])。结论 这些发现支持使用 N2 振幅作为 ASD 学龄儿童执行功能的生物测量。意义 这项研究解决了临床神经生理学中的一个关键空白，因为需要了解 N2 成分的稳定性和可靠性，以便区分重复测量与靶向治疗和干预所解释的差异。