Neurocognitive markers of childhood abuse in individuals with PTSD: Findings from the INTRuST Clinical Consortium.,Journal of Psychiatric Research

当前位置： X-MOL 学术 › J. Psychiatr. Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Neurocognitive markers of childhood abuse in individuals with PTSD: Findings from the INTRuST Clinical Consortium.
Journal of Psychiatric Research ( IF 4.8 ) Pub Date : 2019-11-23 , DOI: 10.1016/j.jpsychires.2019.11.012
Jessica Bomyea ₁ , Alan N Simmons ₁ , Martha E Shenton ₂ , Michael J Coleman ₃ , Sylvain Bouix ₃ , Yogesh Rathi ₃ , Ofer Pasternak ₄ , Raul Coimbra ₅ , Lori Shutter ₆ , Mark S George ₇ , Gerald Grant ₈ , Ross D Zafonte ₉ , Thomas W McAllister ₁₀ , Murray B Stein ₁₁ ,

Affiliation

Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, 92161, USA; Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA.
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 1249 Boylston St, Boston, MA, 02215, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA; VA Boston Healthcare System, Brockton Division, Brockton, MA, 02301, USA.
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 1249 Boylston St, Boston, MA, 02215, USA.
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 1249 Boylston St, Boston, MA, 02215, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Department of Surgery, University of California San Diego, La Jolla, CA, 92161, USA.
University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.
Medical University of South Carolina, Ralph H. Johnson VA Medical Center, Charleston, SC, 29401, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, 29401, USA.
Stanford University Medical Center, Palo Alto, CA, 94305, USA; Duke University, Durham, NC, 90586, USA.
Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02215, USA.
Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA; Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA; University of California, San Diego Department of Family Medicine and Public Health, La Jolla, CA, 92093, USA.

To date, few studies have evaluated the contribution of early life experiences to neurocognitive abnormalities observed in posttraumatic stress disorder (PTSD). Childhood maltreatment is common among individuals with PTSD and is thought to catalyze stress-related biobehavioral changes that might impact both brain structure and function in adulthood. The current study examined differences in brain morphology (brain volume, cortical thickness) and neuropsychological performance in individuals with PTSD characterized by low or high self-reported childhood maltreatment, compared with healthy comparison participants. Data were drawn from the INjury and TRaUmatic STress (INTRuST) Clinical Consortium imaging repository, which contains MRI and self-report data for individuals classified as PTSD positive (with and without a history of mild traumatic brain injury [mTBI]), individuals with mTBI only, and healthy comparison participants. The final sample included 36 individuals with PTSD without childhood maltreatment exposure (PTSD, n = 30 with mTBI), 31 individuals with PTSD and childhood maltreatment exposure (PTSD + M, n = 26 with mTBI), and 114 healthy comparison participants without history of childhood maltreatment exposure (HC). The PTSD + M and PTSD groups demonstrated cortical thinning in prefrontal and occipital regions, and poorer verbal memory and processing speed compared to the HC group. PTSD + M participants demonstrated cortical thinning in frontal and cingulate regions, and poorer executive functioning relative to the PTSD and HC groups. Thus, neurocognitive features varied between individuals with PTSD who did versus did not have exposure to childhood maltreatment, highlighting the need to assess developmental history of maltreatment when examining biomarkers in PTSD.

中文翻译：

PTSD患者中儿童虐待的神经认知标记：INTRuST临床协会的发现。

迄今为止，很少有研究评估早期生活经历对创伤后应激障碍（PTSD）中观察到的神经认知异常的贡献。儿童期虐待在PTSD患者中很常见，并被认为会催化与压力相关的生物行为变化，这可能会影响成年期的大脑结构和功能。当前的研究检查了与健康比较参与者相比，以低或高自我报告的儿童期虐待为特征的PTSD患者的脑形态（大脑容量，皮层厚度）和神经心理表现的差异。数据来自伤害和创伤性压力（INTRuST）临床协会成像库，其中包含归类为PTSD阳性的个体（有无轻度脑外伤史[mTBI]），仅患有mTBI的个体以及健康比较参与者的MRI和自我报告数据。最终样本包括36例未患儿童虐待的PTSD患者（PTSD，mTBI为30例），31例PTSD和患儿童虐待的儿童（PTSD + M，mTBI为n = 26），以及114名没有患病史的健康对照者儿童虐待（HC）。与HC组相比，PTSD + M和PTSD组在前额叶和枕叶区域显示皮质变薄，并且言语记忆和处理速度较差。PTSD + M参与者表现出额叶和扣带状区域的皮质变薄，并且相对于PTSD和HC组而言，执行功能较差。因此，

更新日期：2019-11-26

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>