Objective

To evaluate the association between prenatal selective serotonin reuptake inhibitor (SSRI) exposure and postnatal therapeutic hypothermia for suspected hypoxic ischemic encephalopathy.

Study design

Matched case-control study of singleton deliveries at a tertiary hospital from 2010 to 2016. Cases were infants treated with therapeutic hypothermia for suspected hypoxic ischemic encephalopathy. Controls were noncase infants, matched on gestational age, maternal age, obstetric provider group, and hospital shift.

Result

Prenatal SSRI exposure occurred in 18.4% of cases compared with 4.1% of controls (aOR: 5.9, 95% CI: 1.8–19.7). Among all cases, 36.8% had evidence of hypoxic ischemic encephalopathy on postnatal MRI. In addition, 28.6% of SSRI-exposed cases and 38.7% of SSRI-unexposed cases had MRI confirmation of hypoxic ischemic encephalopathy, respectively.

Conclusion

Future research to disentangle signs of SSRI exposure from true hypoxic ischemic encephalopathy may facilitate targeting therapeutic hypothermia stewardship toward infants more likely to benefit.

中文翻译：

---

产前选择性血清素再摄取抑制剂和低温治疗疑似缺氧缺血性脑病。

客观的

评估产前选择性血清素再摄取抑制剂（SSRI）暴露与产后疑似缺氧缺血性脑病的低温治疗之间的关联。

学习规划

2010年至2016年某三级医院单胎分娩的匹配病例对照研究。病例是因疑似缺氧缺血性脑病而接受低温治疗的婴儿。对照组是非病例婴儿，在胎龄、产妇年龄、产科提供者组和医院轮班方面进行匹配。

结果

18.4% 的病例发生产前 SSRI 暴露，而对照组为 4.1%（aOR：5.9，95% CI：1.8-19.7）。在所有病例中，36.8% 的产后 MRI 有缺氧缺血性脑病证据。此外，28.6%的SSRI暴露病例和38.7%的SSRI未暴露病例分别有MRI证实为缺氧缺血性脑病。

结论

未来研究将 SSRI 暴露与真正的缺氧缺血性脑病联系起来，可能有助于将治疗性低温管理瞄准更有可能受益的婴儿。